Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder

被引：40
作者：
Li, Lingjiang
Chen, Shulin [1 ]
Liu, Jun
Zhang, Jinli
He, Zhong
Lin, Xu
机构：
[1] Seventh Hosp Hangzhou, Dept Clin Psychol, Hangzhou 310013, Zhejiang, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Huna, Peoples R China
[3] Cent S Univ, Xiangya Hosp 2, Dept Radiat, Changsha, Huna, Peoples R China
[4] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming, Yunan, Peoples R China
[5] Chinese Acad Sci, Lab Learning & Memory, Kunming Inst Zool, Kunming, Yunan, Peoples R China
来源：
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2006年 / 51卷 / 07期
关键词：
hippocampus; posttraumatic stress disorder; magnetic resonance imaging; magnetic resonance spectroscopy;
D O I：
10.1177/070674370605100704
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: To explore hippocampal structural abnormalities in fire victims with recent-onset posttraumatic stress disorder (PTSD). Method: We compared 12 patients with recent-onset PTSD diagnosed according to DSM-IV criteria 6 to 8 months after a major fire with 12 individuals without PTSD who were victims of the same fire accident. Voxel-based morphometry (VBM) and magnetic resonance spectroscopy (MRS) were combined to examine hippocampal structural abnormalities in patients with recent-onset PTSD. Results: Results of VBM showed that the grey matter density of the left hippocampus was lower in the group with PTSD than it was in the group without PTSD. Results of MRS showed that the ratio of N-acetyl asparate and creatine in the left hippocampus was significantly lower in patients with PTSD than in control subjects. Conclusion: Patients with recent-onset PTSD had hippocampal structural abnormalities.
引用
收藏
页码：431 / 437
页数：7
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