Histopathology of B-cell chronic lymphocytic leukemia

被引:4
作者
Pileri, SA
Sabattini, E
Agostinelli, C
Bodega, L
Rossi, M
Zinzani, PL
Marafioti, T
机构
[1] Univ Bologna, Inst Haematol & Clin Oncol L&A Seragnoli, Unit Haematopathol, I-40138 Bologna, Italy
[2] Univ Bologna, Inst Heamatol & Clin Oncol L&A Seragnoli, Clin Unit, I-40138 Bologna, Italy
[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9SP, England
关键词
D O I
10.1016/j.hoc.2004.04.010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Histologic and immunohistologic findings of B-cell chronic lymphocytic leukemia/small lymphocytic leukemia are revised in the light of the more recent knowledge on the pathobiology of the disease. The guidelines for the optimal handling of the bioptic samples are provided. The relevance of the examination of trephines, and surgical specimens is outlined with special reference to the identification of risk factors in individual patients.
引用
收藏
页码:807 / +
页数:21
相关论文
共 56 条
[11]   B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes [J].
Damle, RN ;
Ghiotto, F ;
Valetto, A ;
Albasiano, E ;
Fais, F ;
Yan, XJ ;
Sison, CP ;
Allen, SL ;
Kolitz, J ;
Schulman, P ;
Vinciguerra, VP ;
Budde, P ;
Frey, J ;
Rai, KR ;
Ferrarini, M ;
Chiorazzi, N .
BLOOD, 2002, 99 (11) :4087-4093
[12]   HISTOLOGICAL AND IMMUNOHISTOLOGICAL ANALYSIS OF HUMAN LYMPHOMAS [J].
FALINI, B ;
PILERI, S ;
MARTELLI, MF .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 1989, 9 (04) :351-419
[13]   A monoclonal antibody (MUM1p) detects expression of the MUM 1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells [J].
Falini, B ;
Fizzotti, M ;
Pucciarini, A ;
Bigerna, B ;
Marafioti, T ;
Gambacorta, M ;
Pacini, R ;
Alunni, C ;
Natali-Tanci, L ;
Ugolini, B ;
Sebastiani, C ;
Cattoretti, G ;
Pileri, S ;
Dalla-Favera, R ;
Stein, H .
BLOOD, 2000, 95 (06) :2084-2092
[14]  
FERRI C, 2000, VIRAL BACTERIAL PARA, P349
[15]  
Flenghi L, 1996, AM J PATHOL, V148, P1543
[16]   Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia [J].
Granziero, L ;
Ghia, P ;
Circosta, P ;
Gottardi, D ;
Strola, G ;
Geuna, M ;
Montagna, L ;
Piccoli, P ;
Chilosi, M ;
Caligaris-Cappio, F .
BLOOD, 2001, 97 (09) :2777-2783
[17]   CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease [J].
Hamblin, TJ ;
Orchard, JA ;
Ibbotson, RE ;
Davis, Z ;
Thomas, PW ;
Stevenson, FK ;
Oscier, DG .
BLOOD, 2002, 99 (03) :1023-1029
[18]   Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia [J].
Hamblin, TJ ;
Davis, Z ;
Gardiner, A ;
Oscier, DG ;
Stevenson, FK .
BLOOD, 1999, 94 (06) :1848-1854
[19]  
HARRIS NL, 1994, BLOOD, V84, P1361
[20]   CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia [J].
Ibrahim, S ;
Keating, M ;
Do, KA ;
O'Brien, S ;
Huh, YO ;
Jilani, I ;
Lerner, S ;
Kantarjian, HM ;
Albitar, M .
BLOOD, 2001, 98 (01) :181-186