Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure

被引：38
作者：
Dong, Fan [1 ]
Xu, Tianyuan [2 ]
Shen, Yifan [1 ]
Zhong, Shan [1 ]
Chen, Shanwen [1 ]
Ding, Qiang [1 ]
Shen, Zhoujun [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Fudan Inst Urol, Dept Urol, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Urol, Shanghai, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 16期
基金：
中国国家自然科学基金;
关键词：
microRNA; bladder cancer; expression profile; biogenesis procedure; TRANSITIONAL-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; DOWN-REGULATION; MICRORNA EXPRESSION; TUMOR-SUPPRESSOR; NONINVASIVE BIOMARKERS; UROTHELIAL CARCINOMA; POOR-PROGNOSIS; INHIBITS PROLIFERATION; INVASIVE PHENOTYPE;
D O I：
10.18632/oncotarget.15173
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aberrant expression profiles of miRNAs are widely observed in the clinical tissue specimens and urine samples as well as the blood samples of bladder cancer patients. These profiles are closely related to the pathological features of bladder cancer, such as the tumour stage/grade, metastasis, recurrence and chemo-sensitivity. MiRNA biogenesis forms the basis of miRNA expression and function, and its dysregulation has been shown to be essential for variations in miRNA expression profiles as well as tumourigenesis and cancer progression. In this review, we summarize the up-to-date and widely reported miRNAs in bladder cancer that display significantly altered expression. We then compare the miRNA expression profiles among three different sample types (tissue, urine and blood) from patients with bladder cancer. Moreover, for the first time, we outline the dysregulated miRNA biogenesis network in bladder cancer from different levels and analyse its possible relationship with aberrant miRNA expression and the pathological characteristics of the disease.
引用
收藏
页码：27547 / 27568
页数：22
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