Autologous haematopoietic cell transplantation in elderly patients with multiple myeloma

被引：21

作者：

Auner, Holger W. ^{[1
,2
]}

Garderet, Laurent ^{[2
,3
]}

Kroeger, Nicolaus ^{[2
,4
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, London, England

[2] Chron Malignancies Working Party European Soc Blo, Hamburg, Germany

[3] Hop St Antoine, F-75571 Paris, France

[4] Univ Med Ctr, Hamburg, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 171卷 / 04期

关键词：

Autologous haematopoietic cell transplantation; multiple myeloma; elderly patients; comorbidities; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; BLOOD STEM-CELLS; GREATER-THAN-OR-EQUAL-TO-70; YEARS; COMORBIDITY INDEX; YOUNGER PATIENTS; SURVIVAL; MELPHALAN; AGE; IMPROVEMENT;

D O I：

10.1111/bjh.13608

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-dose chemotherapy with melphalan followed by autologous haematopoietic cell transplantation (AHCT) is a standard of care in young patients (<65years) with multiple myeloma. Most myeloma patients, however, are older than 65years at the time of diagnosis, and the findings of numerous single-centre and registry studies provide evidence that AHCT can be a feasible and effective treatment option in these patients. Nevertheless, AHCT is not generally recommended as standard treatment in the elderly, due to the fact that a benefit of AHCT over conventional-dose therapy has not been demonstrated by prospective randomized trials. Yet, the use of AHCT has increased substantially in older patients in recent years, and an increasing number of reports suggest comparable outcomes for older and younger patients after AHCT. In this review we summarize the results of AHCT for elderly patients with multiple myeloma.

引用

页码：453 / 462

页数：10

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