Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies

被引：4
作者：
Fan, Lijuan [1 ]
Fu, Guoning [1 ]
Ding, Yuanyuan [1 ]
Lv, Peng [1 ]
Li, Hongyun [1 ]
机构：
[1] Jining First Peoples Hosp, Dept Gastroenterol, 6 Hlth Rd, Jining 272000, Shandong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 2017年 / 32卷 / 03期
关键词：
Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Bactericidal/permeability increasing protein; Polymorphism; ASSOCIATION; POPULATION; RISK; BPI;
D O I：
10.1007/s00384-016-2740-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Bactericidal/permeability increasing protein (BPI) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between BPI gene polymorphisms and the risk of IBD, Crohn's disease (CD), and ulcerative colitis (UC). Eligible studies from PubMed, Embase, and Cochrane library databases were identified. Ten studies (five CD and five UC) published in five papers were included in this meta-analysis. G645A polymorphism was associated with a decreased risk of UC in allele model, dominant model, and homozygous model. Our data suggested that BPI G645A polymorphism was associated with a decreased risk of UC; the BPI G645A polymorphism was not associated with the risk of CD.
引用
收藏
页码：433 / 435
页数：3
相关论文
共 11 条
[1]   Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease [J].
Akin, Hakan ;
Tahan, Gulgun ;
Ture, Filiz ;
Eren, Fatih ;
Atug, Ozlen ;
Tahan, Veysel ;
Hamzaoglu, Ismail ;
Imeryuz, Nese ;
Tozun, Nurdan ;
Hamzaoglu, Hulya Over .
JOURNAL OF CROHNS & COLITIS, 2011, 5 (01) :14-18
[2]   Bactericidal Permeability Increasing Protein Gene Polymorphism is Associated with Inflammatory Bowel Diseases in the Turkish Population [J].
Can, Guray ;
Akin, Hakan ;
Ozdemir, Filiz T. ;
Can, Hatice ;
Yilmaz, Bulent ;
Eren, Fatih ;
Atug, Ozlen ;
Unsal, Belkis ;
Hamzaoglu, Hulya O. .
SAUDI JOURNAL OF GASTROENTEROLOGY, 2015, 21 (04) :239-244
[3]   Clinical aspects and pathophysiology of inflammatory bowel disease [J].
Hendrickson, BA ;
Gokhale, R ;
Cho, JH .
CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (01) :79-+
[4]   Quantifying heterogeneity in a meta-analysis [J].
Higgins, JPT ;
Thompson, SG .
STATISTICS IN MEDICINE, 2002, 21 (11) :1539-1558
[5]   Depression and risk for Alzheimer disease - Systematic review, meta-analysis, and metaregression analysis [J].
Ownby, RL ;
Crocco, E ;
Acevedo, A ;
John, V ;
Loewenstein, D .
ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (05) :530-538
[6]   Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort [J].
Petermann, Ivonne ;
Huebner, Claudia ;
Browning, Brian L. ;
Gearry, Richard B. ;
Barclay, Murray L. ;
Kennedy, Martin ;
Roberts, Rebecca ;
Shelling, Andrew N. ;
Philpott, Martin ;
Han, Dug Yeo ;
Ferguson, Lynnette R. .
HUMAN IMMUNOLOGY, 2009, 70 (06) :440-446
[7]   Comparison of two methods to detect publication bias in meta-analysis [J].
Peters, JL ;
Sutton, AJ ;
Jones, DR ;
Abrams, KR ;
Rushton, L .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (06) :676-680
[8]   The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease [J].
Schultz, Hendrik ;
Weiss, Jerrold P. .
CLINICA CHIMICA ACTA, 2007, 384 (1-2) :12-23
[9]   Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses [J].
Stang, Andreas .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2010, 25 (09) :603-605
[10]   Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease:: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis [J].
Török, HP ;
Glas, J ;
Tonenchi, L ;
Mussack, T ;
Folwacznya, C .
CLINICAL IMMUNOLOGY, 2004, 112 (01) :85-91
12