Pycnogenol® prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment

被引：0

作者：

Belcaro, Gianni ^{[1
,2
]}

Cornelli, Umberto ^{[1
,2
]}

Dugall, Mark ^{[1
,2
]}

Cotellese, Roberto ^{[1
,2
]}

Feragalli, Beatrice ^{[1
,2
]}

Cesarone, Maria R. ^{[1
,2
]}

机构：

[1] Chieti Pescara Univ, IRVINE3 Labs, Chieti, Italy

[2] Int Agcy Pharma Stand Supplements IAPPS, Chieti, Italy

来源：

MINERVA ENDOCRINOLOGICA | 2019年 / 44卷 / 02期

关键词：

Oxidative stress; Hypothyroidism; Thyroxine; Pycnogenol (R); END-PRODUCTS; OSTEOARTHRITIS; ACID;

D O I：

10.23736/S0391-1977.18.02821-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: In this study we aimed to evaluate the efficacy of Pycnogenol (R) supplementation in controlling oxidative stress levels and in reducing the frequency and severity of side effects of levothyroxine (LT4) treatment in patients who had recently started this therapy. METHODS: The registry included 60 females affected by primary hypothyroidism with multi-nodular goiter. LT4 was administered at the dosage of 100 mu g/day. The registry study included only subjects under initial treatment, and followed up for a period of at least 30 days. A group took 150 mg Pycnogenol (R) daily and another served as control. RESULTS: The global occurrence of symptoms during the 30-day period was significantly lower with the supplement (P<0.05). CONCLUSIONS: Pycnogenol (R) may represent a useful tool to reduce LT4-related side effects in patients treated with hormone replacement therapy for hypothyroidism.

引用

页码：199 / 204

页数：6

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