Neuropathological and genetic findings in autism: The significance of a putative mini columnopathy

被引：61
作者：
Casanova, Manuel F. [1 ]
机构：
[1] Univ Louisville, Dept Psychiat & Behav Sci, Louisville, KY 40292 USA
来源：
NEUROSCIENTIST | 2006年 / 12卷 / 05期
关键词：
autistic disorder/pathology; child development disorders; pervasive; neocortex; neuropil; pyramidal cells;
D O I：
10.1177/1073858406290375
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between mini-columns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism.
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收藏
页码：435 / 441
页数：7
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