Strained-cyclophane-induced β-turn template:: Design, synthesis, and spectroscopic characterization

被引：25

作者：

Cristau, P ^{[1
]}

Martin, MT

Dau, METH

Vors, JP

Zhu, JP

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Bayer CropSci, F-69009 Lyon, France

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 18期

关键词：

D O I：

10.1021/ol0488439

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three tetrapeptides incorporating a 14-membered (Ri+1, Si+2) cycloisodityrosine at the i + 1 and i + 2 positions were designed and synthesized. Conformational analysis by H-1 NMR and CD spectra as well as molecular modeling indicated that they all adopt a beta-turn conformation. While the CD spectrum of compound 2 is characteristic of the typical type-II beta-turn (maximum at similar to200 nm and a minimum at similar to220 nm), that of 1a (atropisomer of 2) is opposite in sign to the expected spectrum of the type-II beta-turn.

引用

页码：3183 / 3186

页数：4

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