HETEROCYCLES 40. THE LIPOPHILICITY EVALUATION OF SOME NEW PYRIDIN-3/4-YL-THIAZOLO [3,2-B] [1,2,4]TRIAZOLE COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY BY RP-TLC AND COMPUTATIONAL METHODS

A series of new pyridin-3/4-yl-thiazolo[3,2-b][1,2,4]triazole compounds and their corresponding thioetheric intermediates with anti-inflammatory activity were evaluated in order to establish their lipophilic profile by reversed phase thin layer chromatography (RP-TLC). The lipophilicity parameters were determined experimentally, based on the chromatographic data (R-M, R-mo, b, mRM, phi(0), PC1/R-M). A series of theoretical lipophilicity indices were estimated with different computational methods. A good correlation was observed between the experimental lipophilicity parameters and the computed logP values (R-2 >+/- 0.83). The scores obtained by applying the principal components analysis (PCA) classify the investigated compounds into three groups, their repartition being correlated with the chemical structure and the anti-inflammatory activity.