Notch signaling in neuroblastoma

被引：59

作者：

Påhlman, S ^{[1
]}

Stockhausen, MT ^{[1
]}

Fredlund, E ^{[1
]}

Axelson, H ^{[1
]}

机构：

[1] Lund Univ, Univ Hosp MAS, Div Mol Med, Dept Lab Med, SE-20502 Malmo, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 05期

关键词：

neuroblastoma; notch; Hes; differentiation; normoxia; hypoxia;

D O I：

10.1016/j.semcancer.2004.04.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroblastoma is a pediatric tumor that originates from precursor cells of the sympathetic nervous system that have discontinued their normal differentiation program. This review is focused on involvement of the Notch signaling cascade in the process of differentiation in neuroblastoma cells and normal cells of the sympathetic nervous system. Hypoxia induces dedifferentiation of neuroblastoma cells in vivo and in vitro, and under oxygen-compromised conditions the Notch cascade is activated. This activation might promote development of the dedifferentiated phenotype. The implications of these observations for tumor biology are also discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：365 / 373

页数：9

共 61 条

[1] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[2] Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1β and amyloid β42 peptide is potentiated by hypoxia in primary human neural cells [J].

Bazan, NG ;

Lukiw, WJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :30359-30367

[3] Levels of hypoxia-inducible factor-1α during breast carcinogenesis [J].

Bos, R ;

Zhong, H ;

Hanrahan, CF ;

Mommers, ECM ;

Semenza, GL ;

Pinedo, HM ;

Abeloff, MD ;

Simons, JW ;

van Diest, PJ ;

van der Wall, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (04) :309-314

[4] Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma [J].

Bown, N ;

Cotterill, S ;

Lastowska, M ;

O'Neill, S ;

Pearson, ADJ ;

Plantaz, D ;

Meddeb, M ;

Danglot, G ;

Brinkschmidt, C ;

Christiansen, H ;

Laureys, G ;

Speleman, F .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (25) :1954-1961

[5] REVISIONS OF THE INTERNATIONAL CRITERIA FOR NEUROBLASTOMA DIAGNOSIS, STAGING, AND RESPONSE TO TREATMENT [J].

BRODEUR, GM ;

PRITCHARD, J ;

BERTHOLD, F ;

CARLSEN, NLT ;

CASTEL, V ;

CASTLEBERRY, RP ;

DEBERNARDI, B ;

EVANS, AE ;

FAVROT, M ;

HEDBORG, F ;

KANEKO, M ;

KEMSHEAD, J ;

LAMPERT, F ;

LEE, REJ ;

LOOK, AT ;

PEARSON, ADJ ;

PHILIP, T ;

ROALD, B ;

SAWADA, T ;

SEEGER, RC ;

TSUCHIDA, Y ;

VOUTE, PA .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (08) :1466-1477

[6]

BRODEUR GM, 1981, CANCER RES, V41, P4678

[7] Neuroblastoma: Biological insights into a clinical enigma [J].

Brodeur, GM .

NATURE REVIEWS CANCER, 2003, 3 (03) :203-216

[8]

CICCARONE V, 1989, CANCER RES, V49, P219

[9] EXPRESSION OF AN EXTRACELLULAR DELETION OF XOTCH DIVERTS CELL FATE IN XENOPUS-EMBRYOS [J].

COFFMAN, CR ;

SKOGLUND, P ;

HARRIS, WA ;

KINTNER, CR .

CELL, 1993, 73 (04) :659-671

[10]

COHEN PS, 1994, BLOOD, V84, P3465

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