Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma

被引：2

作者：

Turk, Andrew T. ^{[1
]}

Garcia-Carracedo, Dario ^{[2
]}

Kent, David T. ^{[3
]}

Philipone, Elizabeth ^{[1
]}

Maria Garcia-Pedrero, Juana ^{[4
,5
]}

Caruana, Salvatore M. ^{[2
]}

Close, Lanny G. ^{[2
]}

Su, Gloria H. ^{[2
]}

机构：

[1] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[2] Columbia Univ, Dept Otolaryngol, New York, NY 10032 USA

[3] Vanderbilt Univ, Dept Otolaryngol, Nashville, TN 37232 USA

[4] Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo 33006, Spain

[5] Inst Univ Oncol Principado Asturias, Oviedo 33006, Spain

来源：

GENES & DISEASES | 2022年 / 9卷 / 03期

关键词：

Cancer; Head & neck squamous cell carcinoma; Pathology; Stathmin; PTEN EXPRESSION; POOR-PROGNOSIS;

D O I：

10.1016/j.gendis.2020.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to assess Stathmin as an immunohistochemical (IHC) indicator of phosphatidylinositol 3-kinase (PI3K) pathway activity in HPV-negative head & neck squamous cell carcinoma (HNSCC), we compared Stathmin IHC to expression of other pathway components. We also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway genes. Finally, we ascertained whether Stathmin IHC correlates with tumor grade or primary site. Correlation exists between high Stathmin expression and high pAKT1 expression, indicating a role for Stathmin IHC as a marker of pathway activity. Our analysis did not show correlation between Stathmin IHC and mutation of the four genes evaluated. We also observed an association between high Stathmin expression and oropharyngeal primary site. Our results suggest utility of Stathmin IHC as an indicator of PI3K pathway activity, and thereby demonstrate potential relevance of Stathmin IHC in the context of HNSCC. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：820 / 825

页数：6

共 17 条

[1] Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors [J].

Andersen, Jannik N. ;

Sathyanarayanan, Sriram ;

Di Bacco, Alessandra ;

Chi, An ;

Zhang, Theresa ;

Chen, Albert H. ;

Dolinski, Brian ;

Kraus, Manfred ;

Roberts, Brian ;

Arthur, William ;

Klinghoffer, Rich A. ;

Gargano, Diana ;

Li, Lixia ;

Feldman, Igor ;

Lynch, Bethany ;

Rush, John ;

Hendrickson, Ronald C. ;

Blume-Jensen, Peter ;

Paweletz, Cloud P. .

SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (43)

[2] Low PTEN expression is associated with worse overall survival in head and neck squamous cell carcinoma patients treated with chemotherapy and cetuximab [J].

da Costa, Alexandre A. B. A. ;

Costa, Felipe D'Almeida ;

Ribeiro, Adriana R. ;

Guimaraes, Andreia P. ;

Chinen, Ludmila T. ;

Lopes, Clovis A. P. ;

de Lima, Vladmir C. C. .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2015, 20 (02) :282-289

[3] From signaling pathways to microtubule dynamics: the key players [J].

Etienne-Manneville, Sandrine .

CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (01) :104-111

[4] Loss of PTEN Expression Is Associated with Poor Prognosis in Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas [J].

Garcia-Carracedo, Dario ;

Turk, Andrew T. ;

Fine, Stuart A. ;

Akhavan, Nathan ;

Tweel, Benjamin C. ;

Parsons, Ramon ;

Chabot, John A. ;

Allendorf, John D. ;

Genkinger, Jeanine M. ;

Remotti, Helen E. ;

Su, Gloria H. .

CLINICAL CANCER RESEARCH, 2013, 19 (24) :6830-6841

[5]

Gupta AK, 2002, CLIN CANCER RES, V8, P885

[6]

Kurasawa Y, 2008, ONCOL REP, V19, P1429

[7] Comprehensive genomic characterization of head and neck squamous cell carcinomas [J].

Lawrence, Michael S. ;

Sougnez, Carrie ;

Lichtenstein, Lee ;

Cibulskisl, Kristian ;

Lander, Eric ;

Gabriel, Stacey B. ;

Getz, Gad ;

Ally, Adrian ;

Balasundaram, Miruna ;

Birol, Inanc ;

Bowlby, Reanne ;

Brooks, Denise ;

Butterfield, Yaron S. N. ;

Carlsen, Rebecca ;

Cheng, Dean ;

Chu, Andy ;

Dhalla, Noreen ;

Guin, Ranabir ;

Holt, Robert A. ;

Jones, Steven J. M. ;

Lee, Darlene ;

Li, Haiyan I. ;

Marra, Marco A. ;

Mayo, Michael ;

Moore, Richard A. ;

Mungall, Andrew J. ;

Robertson, A. Gordon ;

Schein, Jacqueline E. ;

Sipahimalan, Payal ;

Tam, Angela ;

Thiessen, Nina ;

Wong, Tina ;

Protopopov, Alexei ;

Santoso, Netty ;

Lee, Semin ;

Parfenov, Michael ;

Zhang, Jianhua ;

Mahadeshwar, Harshad S. ;

Tang, Jiabin ;

Ren, Xiaojia ;

Seth, Sahil ;

Haseley, Psalm ;

Zeng, Dong ;

Yang, Lixing ;

Xu, Andrew W. ;

Song, Xingzhi ;

Pantazi, Angeliki ;

Bristow, Christopher A. ;

Hadjipanayis, Angela ;

Seidman, Jonathan .

NATURE, 2015, 517 (7536) :576-582

[8] Akt activation correlates with adverse outcome in tongue cancer [J].

Massarelli, E ;

Liu, DD ;

Lee, JJ ;

El-Naggar, AK ;

Lo Muzio, L ;

Staibano, S ;

De Placido, S ;

Myers, JN ;

Papadimitrakopoulou, VA .

CANCER, 2005, 104 (11) :2430-2436

[9] Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma [J].

Monteiro, Luis Silva ;

Delgado, Maria Leonor ;

Ricardo, Sara ;

Garcez, Fernanda ;

do Amaral, Barbas ;

Warnakulasuriya, Saman ;

Lopes, Carlos .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2013, 115 (05) :638-645

[10] The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers Insights From a Precision Oncology Sequencing Platform [J].

Morris, Luc G. T. ;

Chandramohan, Raghu ;

West, Lyndsay ;

Zehir, Ahmet ;

Chakravarty, Debyani ;

Pfister, David G. ;

Wong, Richard J. ;

Lee, Nancy Y. ;

Sherman, Eric J. ;

Baxi, Shrujal S. ;

Ganly, Ian ;

Singh, Bhuvanesh ;

Shah, Jatin P. ;

Shaha, Ashok R. ;

Boyle, Jay O. ;

Patel, Snehal G. ;

Roman, Benjamin R. ;

Barker, Christopher A. ;

McBride, Sean M. ;

Chan, Timothy A. ;

Dogan, Snjezana ;

Hyman, David M. ;

Berger, Michael F. ;

Solit, David B. ;

Riaz, Nadeem ;

Ho, Alan L. .

JAMA ONCOLOGY, 2017, 3 (02) :244-255

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