Fluorous-tethered amine bases for organic and parallel synthesis: scope and limitations

被引：22

作者：

Lindsley, CW ^{[1
]}

Zhao, ZJ ^{[1
]}

Leister, WH ^{[1
]}

Strauss, KA ^{[1
]}

机构：

[1] Merck Res Labs, Technol Enabled Synth Grp, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 36期

关键词：

fluorous; amines; combinatorial chemistry;

D O I：

10.1016/S0040-4039(02)01399-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of fluorous-tethered amine bases is described. These novel fluorous-tethered reagents promote reactions, remove acidic by-products, and scavenge electrophiles. They are readily separated from the reaction mixture by solid phase extraction on a novel mixed sorbent SPE (SCX/fluorous silica gel) delivering products in high yields and purities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6319 / 6323

页数：5

共 7 条

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Lindsley, CW
Zhao, Z
Newton, RC
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Lindsley, CW
Zhao, Z
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[J]. TETRAHEDRON LETTERS, 2002, 43 (23) : 4225 - 4228
[6] LOU ZY, 2001, J ORG CHEM, V66, P4261
[7] Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis
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Curran, DP
Chen, CHT
[J]. TETRAHEDRON, 2002, 58 (20) : 3871 - 3875

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