Efficacy of repeated low-dose bevacizumab treatment with long-dosing interval for radiation-induced brain necrosis: A case report

被引：3
作者：
Meng, Xiangying [1 ]
Zhao, Rugang [2 ]
Wu, Shikai [1 ]
Shen, Ge [1 ]
Ding, Lijuan [1 ]
Sun, Bing [1 ]
Wang, Junliang [1 ]
机构：
[1] Acad Mil Med Sci, Affiliated Hosp, Dept Radiat Oncol, Beijing 100071, Peoples R China
[2] Navy Gen Hosp, Radiotherapy Dept, Beijing, Peoples R China
来源：
CANCER BIOLOGY & THERAPY | 2017年 / 18卷 / 01期
关键词：
Bevacizumab; breast carcinoma; metastasisradiation-induced brain necrosis; CANCER; GLIOMA;
D O I：
10.1080/15384047.2016.1276127
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 40-year-old Chinese female patient, with radiation-induced brain necrosis after radiosurgery, was treated 6times with a single dose of 200mg (3.27mg/kg) bevacizumab each time, and with an interval of 12-16weeks between each treatment. Neurological symptoms such as dizziness, fatigue, and headache disappeared after each administration of bevacizumab. The results suggest that repeated bevacizumab treatment using a low-dose and long-dosing interval may significantly alleviate radiation necrosis and its symptoms.
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收藏
页码：63 / 66
页数：4
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