Highly regio- and chemoselective silylation of diethyl α-hydroxyphosphonates, alcohols and phenols in the presence of solid TiCl3(OTf) as a catalyst with hexamethyldisilazane (HMDS) at room temperature in the absence of solvent

被引：15

作者：

Firouzabadi, Habib ^{[1
]}

Iranpoor, Nasser ^{[1
]}

Farahi, Soghra ^{[1
]}

机构：

[1] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 71454, Iran

来源：

CATALYSIS COMMUNICATIONS | 2009年 / 10卷 / 11期

关键词：

Hexamethyldisilazane; alpha-Hydroxyphosphonate; Alcohol; Phenol; Silylation; Solvent-free; EFFICIENT METHOD; HYDROXYL-GROUPS; SYNTHETIC METHODS; O-SILYLATION; TRIFLATE; ACID; PROTECTION; TRIMETHYLSILYLOXYPHOSPHONATES; ACTIVATION; MILD;

D O I：

10.1016/j.catcom.2009.04.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Solid trichlorotitanium(IV) trifluoromethanesulfonate [TiCl3(OTf)] is an easily prepared compound from the reaction of TiCl4 with trifluoromethanesulfonic acid. This solid Ti(IV) based compound is used as a catalyst for highly efficient silylation of diethyl alpha-hydroxyphosphonates, alcohols and phenols with hexamethyldisilazane (HMDS) at room temperature under solvent-free conditions. Chemo- and regioselectivity for masking different hydroxyl functional groups were observed in the presence of this catalyst. (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：1547 / 1550

页数：4

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