Automatic multispectral MRI segmentation of human hippocampal subfields: an evaluation of multicentric test-retest reproducibility

被引：10

作者：

Chiappiniello, Andrea ^{[1
,2
]}

Tarducci, Roberto ^{[2
]}

Muscio, Cristina ^{[3
]}

Bruzzone, Maria Grazia ^{[4
]}

Bozzali, Marco ^{[5
,6
]}

Tiraboschi, Pietro ^{[3
]}

Nigri, Anna ^{[4
]}

Ambrosi, Claudia ^{[7
]}

Chipi, Elena ^{[8
]}

Ferraro, Stefania ^{[4
]}

Festari, Cristina ^{[9
,10
]}

Gasparotti, Roberto ^{[7
,11
]}

Gianeri, Ruben ^{[4
]}

Giulietti, Giovanni ^{[5
,12
]}

Mascaro, Lorella ^{[13
]}

Montanucci, Chiara ^{[8
]}

Nicolosi, Valentina ^{[9
]}

Rosazza, Cristina ^{[4
]}

Serra, Laura ^{[5
]}

Frisoni, Giovanni B. ^{[9
,14
,15
]}

Perani, Daniela ^{[12
,16
,17
]}

Tagliavini, Fabrizio ^{[3
,18
]}

Jovicich, Jorge ^{[19
]}

机构：

[1] Univ Turin, Dept Phys, Turin, Italy

[2] Osped S Maria Misericordia, Med Phys Dept, Piazzale Giorgio Menghini 1, I-06129 Perugia, Italy

[3] Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol Neuropathol 5, Milan, Italy

[4] Fdn IRCCS Ist Neurol Carlo Besta, Unit Neuroradiol, Milan, Italy

[5] Fdn IRCCS Santa Lucia, Neuroimaging Lab, Rome, Italy

[6] Univ Sussex, Brighton & Sussex Med Sch, Dept Neurosci, Brighton, E Sussex, England

[7] ASST Spedali Civili Brescia, Neuroradiol Unit, Brescia, Italy

[8] Univ Perugia, Ctr Memory Disturbances, Neurol Clin, Lab Clin Neurochem, Perugia, Italy

[9] IRCCS Ist Ctr San Giovanni Di Dio Fatebenefratell, Lab Neuroimaging & Alzheimers Epidemiol, Brescia, Italy

[10] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy

[11] Univ Brescia, Dept Med & Surg Special Radiol Sci & Publ Hlth, Brescia, Italy

[12] Osped San Raffaele, Nucl Med Unit, IRCCS, Milan, Italy

[13] ASST Spedali Civili Brescia, Dept Diagnost Imaging, Med Phys Unit, Brescia, Italy

[14] Univ Geneva, Lab Neuroimaging Aging, LANVIE, Geneva, Switzerland

[15] Univ Hosp, Memory Clin, Geneva, Switzerland

[16] Ist Sci San Raffaele, IRCCS, Div Neurosci, Milan, Italy

[17] Univ Vita Salute San Raffaele, Milan, Italy

[18] Fdn IRCCS Ist Neurol Carlo Besta, Sci Direct, Milan, Italy

[19] Univ Trento, Ctr Mind Brain Sci CIMeC, Rovereto, Italy

来源：

BRAIN STRUCTURE & FUNCTION | 2021年 / 226卷 / 01期

关键词：

Hippocampal subfields; Automated segmentation; FreeSurfer; Test– retest reproducibility; Human brain morphometry; Multispectral MRI; MILD COGNITIVE IMPAIRMENT; HIGH-RESOLUTION MRI; ALZHEIMERS-DISEASE; PARAHIPPOCAMPAL SUBREGIONS; VOLUMES; BRAIN; VIVO; RELIABILITY; AMYGDALA; ASSOCIATION;

D O I：

10.1007/s00429-020-02172-w

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Accurate and reproducible automated segmentation of human hippocampal subfields is of interest to study their roles in cognitive functions and disease processes. Multispectral structural MRI methods have been proposed to improve automated hippocampal subfield segmentation accuracy, but the reproducibility in a multicentric setting is, to date, not well characterized. Here, we assessed test-retest reproducibility of FreeSurfer 6.0 hippocampal subfield segmentations using multispectral MRI analysis pipelines (22 healthy subjects scanned twice, a week apart, at four 3T MRI sites). The harmonized MRI protocol included two 3D-T1, a 3D-FLAIR, and a high-resolution 2D-T2. After within-session T1 averaging, subfield volumes were segmented using three pipelines with different multispectral data: two longitudinal ("long_T1s" and "long_T1s_FLAIR") and one cross-sectional ("long_T1s_FLAIR_crossT2"). Volume reproducibility was quantified in magnitude (reproducibility error-RE) and space (DICE coefficient). RE was lower in all hippocampal subfields, except for hippocampal fissure, using the longitudinal pipelines compared to long_T1s_FLAIR_crossT2 (average RE reduction of 0.4-3.6%). Similarly, the longitudinal pipelines showed a higher spatial reproducibility (1.1-7.8% of DICE improvement) in all hippocampal structures compared to long_T1s_FLAIR_crossT2. Moreover, long_T1s_FLAIR provided a small but significant RE improvement in comparison to long_T1s (p = 0.015), whereas no significant DICE differences were found. In addition, structures with volumes larger than 200 mm(3) had better RE (1-2%) and DICE (0.7-0.95) than smaller structures. In summary, our study suggests that the most reproducible hippocampal subfield FreeSurfer segmentations are derived from a longitudinal pipeline using 3D-T1s and 3D-FLAIR. Adapting a longitudinal pipeline to include high-resolution 2D-T2 may lead to further improvements.

引用

页码：137 / 150

页数：14

共 49 条

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