EFFECTS OF FLUORIDE ON EXPRESSION OF CYTOKINES IN THE HIPPOCAMPUS OF ADULT RATS

被引：0

作者：

Zhou, Bingrui ^{[1
]}

Luo, Guangying ^{[1
]}

Wang, Chong ^{[1
]}

Niu, Ruiyan ^{[1
]}

Wang, Jundong ^{[1
]}

机构：

[1] Shanxi Agr Univ, Shanxi Key Lab Ecol Anim Sci & Environm Med, Taigu 030801, Shanxi, Peoples R China

来源：

FLUORIDE | 2014年 / 47卷 / 03期

关键词：

Cytokine; Fluoride; Hippocampus; TGF-beta; 1; IL-4; IL-1; beta; IL-6; TNF-alpha; OXIDATIVE STRESS; LEARNING-MEMORY; BRAIN; BETA; TOXICITY; MICE;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To investigate the effects of fluoride on the expression levels of cytokines in the rat hippocampus, 60 adult Wistar albino rats were randomly divided into four groups of 15 rats each, whose drinking water contained: (1) double distilled water (the control group); (2) 25 mg sodium fluoride (NaF)/L, (11.3 mg F/L); (3) 50 mg NaF/L, (22.6 mg F/L); and (4) 100 mg NaF/L, (45.2 mg F/L). After five months treatment, the expression levels of the cytokines TGF-beta 1, IL-4, IL-1 beta, IL-6, and TNF-alpha gene were determined by real-time PCR, and the TGF-beta 1 protein levels were detected by ELISA. A significant decrease of TGF-beta 1 was found, in both the gene and protein levels, while no significant change occurred in the levels of IL-4, IL-1 beta, IL-6, and TNF-alpha gene. Fluoride may damage the hippocampus by significantly decreasing the expression of TGF-beta 1 gene and protein, possibly by an unknown post-transcriptional mechanism. The study provides a new perspective for evaluating the neurotoxicity of fluoride.

引用

页码：191 / 198

页数：8

共 27 条

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