The role of fibroblast growth factor-2 in healing the dura mater after inducing cerebrospinal fluid leakage in rats

被引：16

作者：

Nurata, Hakan ^{[2
]}

Cemil, Berker ^{[1
]}

Kurt, Goekhan ^{[3
]}

Ucankus, Nese Lortlar ^{[4
]}

Dogulu, Fikret ^{[3
]}

Omeroglu, Suna ^{[4
]}

机构：

[1] Ankara Numune Training & Res Hosp, Dept Neurosurg, TR-06550 Ankara, Turkey

[2] Ergani State Hosp, Dept Neurosurg, Ergani, Diyarbakir, Turkey

[3] Gazi Univ, Sch Med, Dept Neurosurg, Ankara, Turkey

[4] Gazi Univ, Sch Med, Dept Histol & Embryol, Ankara, Turkey

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 04期

关键词：

Cerebrospinal fluid leakage; Dura mater; Fibroblast growth factor-2; Rat; SCAR FORMATION; MODEL; LAMINECTOMY; SUBSTITUTE; SEALANT; REPAIR;

D O I：

10.1016/j.jocn.2008.05.021

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2-L4 vertebrae, and a dura mater defect was created. Sixteen Fats were treated postoperatively with locally applied recombinant Mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased (p < 0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：542 / 544

页数：3

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