Association between early antibiotic exposure and risk of childhood weight gain and obesity: a systematic review and meta-analysis

被引:15
作者
Aghaali, Mohammad [1 ,2 ]
Hashemi-Nazari, Seyed Saeed [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Epidemiol, Safety Promot & Injury Prevent Res Ctr, Arabi Ave,Daneshjoo Blvd, Tehran, Iran
[2] Qom Univ Med Sci, Sch Med, Dept Epidemiol, Qom, Iran
关键词
anti-bacterial agents; body mass index; meta-analysis; obesity; pediatrics; BODY-MASS INDEX; YOUNG-CHILDREN; GUT MICROBIOTA; LIFE; OVERWEIGHT; INFANCY; ASTHMA; GROWTH;
D O I
10.1515/jpem-2018-0437
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Recent studies have shown that antibiotic exposure during infancy is associated with increased body mass in healthy children. This study was performed to investigate the association between early-life antibiotic exposure and risk of childhood obesity. Methods: A systematic review and meta-analysis was performed to comprehensively and quantitatively determine the association between early antibiotic exposure and risk of childhood obesity. Various databases such as PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane and Google Scholar were searched. A random-effects meta-analysis was performed to pool the statistical estimates. Additionally, a subgroup analysis was performed based on the time of follow-up. Results: Nineteen studies involving at least 671,681 participants were finally included. Antibiotic exposure in early life was significantly associated with risk of childhood weight gain and obesity (odds ratio [OR]: 1.05, 95% confidence interval [CI]: 1.04-1.06). Conclusions: Antibiotic exposure in early life significantly increases the risk of childhood weight gain and obesity.
引用
收藏
页码:439 / 445
页数:7
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