Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-κB

被引：41

作者：

Peloponese, Jean-Marie, Jr. ^{[1
,2
,3
,4
,5
]}

Yasunaga, Junichiro ^{[3
]}

Kinjo, Takao ^{[3
]}

Watashi, Koichi ^{[3
]}

Jeang, Kuan-Teh ^{[3
]}

机构：

[1] Univ Montpellier 1, F-34965 Montpellier, France

[2] Ctr Etud Agents Pathogens & Biotechnol Sante, CNRS, UM5236, F-34965 Montpellier, France

[3] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[4] Univ Montpellier 2, Ctr Etud Agents Pathogenes & Biotechnol Sante, CNRS, UM5236, F-34095 Montpellier, France

[5] Univ Montpellier 2, Ctr Etud Agents Pathogenes & Biotechnol Sante, F-34095 Montpellier, France

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HTLV-I TAX; 1ST HUMAN RETROVIRUS; PROLYL ISOMERASE; CENTROSOME AMPLIFICATION; TRANSCRIPTIONAL ACTIVITY; TRANSFORMING PROTEIN; DNA-DAMAGE; C-FOS; ONCOPROTEIN; CANCER;

D O I：

10.1128/JVI.01824-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL). The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation. ATL is a highly virulent cancer that is resistant to chemotherapeutic treatments. To understand this disease better, it is important to comprehend how HTLV-1 promotes cellular growth and survival. Tax activation of NF-kappa B is important for the proliferation and transformation of virus-infected cells. We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-kappa B activation.

引用

页码：3238 / 3248

页数：11

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