Cluster analysis of the codon use frequency of MHC genes from different species

被引：43

作者：

Ma, JM ^{[1
]}

Zhou, T ^{[1
]}

Gu, WJ ^{[1
]}

Sun, X ^{[1
]}

Lu, ZH ^{[1
]}

机构：

[1] Southeast Univ, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu Provinc, Peoples R China

来源：

BIOSYSTEMS | 2002年 / 65卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

relative synonymous codon use frequency (RSCU); codon usage bias; MHC; hierarchical cluster analysis;

D O I：

10.1016/S0303-2647(02)00016-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relative synonymous codon use frequency of 135 MHC genes from four mammal species (Homo sapiens, Pan troglodyte, Macaca mulanta and Rattus norvegicus) is analyzed using a hierarchical cluster method. The result suggests that gene function is the dominant factor that determines codon usage bias, while species is a minor factor that determines further difference in codon usage bias for genes with similar functions. The conclusion may be useful in gene classification and gene function prediction. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：199 / 207

页数：9

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