Insights into Manganese Superoxide Dismutase and Human Diseases

被引：85
作者：
Liu, Mengfan [1 ,2 ]
Sun, Xueyang [1 ,2 ]
Chen, Boya [1 ,3 ]
Dai, Rongchen [1 ,2 ]
Xi, Zhichao [1 ,2 ]
Xu, Hongxi [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
[2] Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
[3] Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 24期
基金：
英国科研创新办公室; 中国国家自然科学基金;
关键词：
MnSOD; oxidative stress; ROS; human diseases; MnSOD mimetics; INCREASED MITOCHONDRIAL SUPEROXIDE; FOCAL CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; MOUSE MODEL; LIVER FIBROSIS; ENDOTHELIAL DYSFUNCTION; PHYSIOLOGICAL ROLES; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; REPERFUSION INJURY;
D O I：
10.3390/ijms232415893
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Redox equilibria and the modulation of redox signalling play crucial roles in physiological processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant defence, compromising redox homeostasis and increasing oxidative stress, leading to the development of several diseases. Manganese superoxide dismutase (MnSOD) is a principal antioxidant enzyme that protects cells from oxidative damage by converting superoxide anion radicals to hydrogen peroxide and oxygen in mitochondria. Systematic studies have demonstrated that MnSOD plays an indispensable role in multiple diseases. This review focuses on preclinical evidence that describes the mechanisms of MnSOD in diseases accompanied with an imbalanced redox status, including fibrotic diseases, inflammation, diabetes, vascular diseases, neurodegenerative diseases, and cancer. The potential therapeutic effects of MnSOD activators and MnSOD mimetics are also discussed. Targeting this specific superoxide anion radical scavenger may be a clinically beneficial strategy, and understanding the therapeutic role of MnSOD may provide a positive insight into preventing and treating related diseases.
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页数：26
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