Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

被引：8
作者：
Thamban Chandrika, Nishad [1 ]
Dennis, Emily K. [1 ]
Brubaker, Katelyn R. [1 ]
Kwiatkowski, Stefan [1 ,2 ]
Watt, David S. [2 ,3 ]
Garneau-Tsodikova, Sylvie [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut, Lexington, KY 40536 USA
[2] Univ Kentucky, Coll Pharm, Ctr Pharmaceut Res & Innovat, Lexington, KY 40536 USA
[3] Univ Kentucky, Coll Pharm, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA
来源：
CHEMMEDCHEM | 2021年 / 16卷 / 01期
关键词：
Biofilm; Candida auris; Cytotoxicity; Drug resistance; Hemolysis; Monohydrazones; INVASIVE FUNGAL-INFECTIONS; CANDIDA-AURIS; NEW-YORK; EPIDEMIOLOGY; RESISTANCE; HEALTH; DRUGS; ANTIBACTERIAL; DERIVATIVES; MANAGEMENT;
D O I：
10.1002/cmdc.202000626
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevantCandida aurisstrains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed toC. aurisAR Bank # 0390 over 15 passages.
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收藏
页码：124 / 133
页数：10
相关论文
共 56 条
[1]   Candida auris in Healthcare Facilities, New York, USA, 2013-2017 [J].
Adams, Eleanor ;
Quinn, Monica ;
Tsay, Sharon ;
Poirot, Eugenie ;
Chaturvedi, Sudha ;
Southwick, Karen ;
Greenko, Jane ;
Fernandez, Rafael ;
Kallen, Alex ;
Vallabhaneni, Snigdha ;
Haley, Valerie ;
Hutton, Brad ;
Blog, Debra ;
Lutterloh, Emily ;
Zucker, Howard .
EMERGING INFECTIOUS DISEASES, 2018, 24 (10) :1816-1824
[2]   Nosocomial Fungal Infections: Epidemiology, Infection Control, and Prevention [J].
Alangaden, George J. .
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2011, 25 (01) :201-+
[3]   Azole antifungals: 35 years of invasive fungal infection management [J].
Allen, David ;
Wilson, Dustin ;
Drew, Richard ;
Perfect, John .
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2015, 13 (06) :787-798
[4]   New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole [J].
Bendaha, Hasnae ;
Yu, Lisa ;
Touzani, Rachid ;
Souane, Rachid ;
Giaever, Gun I. ;
Nislow, Corey ;
Boone, Charles ;
El Kadiri, Sghir ;
Brown, Grant W. ;
Bellaoui, Mohammed .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :4117-4124
[5]   Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity [J].
Benhamou, Raphael I. ;
Steinbuch, Kfir B. ;
Fridman, Micha .
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (32) :11148-11151
[6]   Epidemiology of invasive fungal infection [J].
Caston-Osorio, J. J. ;
Rivero, A. ;
Torre-Cisneros, J. .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 32 :S103-S109
[7]   N,N′-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents [J].
Chandrika, Nishad Thamban ;
Dennis, Emily K. ;
Shrestha, Sanjib K. ;
Ngo, Huy X. ;
Green, Keith D. ;
Kwiatkowski, Stefan ;
Deaciuc, Agripina Gabriela ;
Dwoskin, Linda P. ;
Watt, David S. ;
Garneau-Tsodikova, Sylvie .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 164 :273-281
[8]   Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities [J].
Chandrika, Nishad Thamban ;
Garneau-Tsodikova, Sylvie .
CHEMICAL SOCIETY REVIEWS, 2018, 47 (04) :1189-1249
[9]   Novel fluconazole derivatives with promising antifungal activity [J].
Chandrika, Nishad Thamban ;
Shrestha, Sanjib K. ;
Ngo, Huy X. ;
Howard, Kaitlind C. ;
Garneau-Tsodikova, Sylvie .
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (03) :573-580
[10]   New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents [J].
Chandrika, Nishad Thamban ;
Shrestha, Sanjib K. ;
Ranjan, Nihar ;
Sharma, Anindra ;
Arya, Dev P. ;
Garneau-Tsodikova, Sylvie .
ACS INFECTIOUS DISEASES, 2018, 4 (02) :196-207
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