Near infrared Raman spectroscopic characterization of blood plasma of normal, oral premalignant and malignant conditions-a pilot study
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Rekha, Pachaiappan
[1
]
Aruna, Prakasarao
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Anna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
Aruna, Prakasarao
[1
]
Bharanidharan, Ganesan
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Anna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
Bharanidharan, Ganesan
[1
]
Koteeswaran, Dornadula
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Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Chennai, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
Koteeswaran, Dornadula
[2
]
Baludavid, Munusamy
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Govt Arignar Anna Mem Canc Hosp, Dept Oncol, Karapettai, Kanchipuram, India
Reg Canc Ctr, Karapettai, Kanchipuram, IndiaAnna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
Baludavid, Munusamy
[3
,4
]
Ganesan, Singaravelu
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Anna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
Ganesan, Singaravelu
[1
]
机构:
[1] Anna Univ, Dept Med Phys, Chennai 600025, Tamil Nadu, India
[2] Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Chennai, Tamil Nadu, India
[3] Govt Arignar Anna Mem Canc Hosp, Dept Oncol, Karapettai, Kanchipuram, India
The metabolic end products from cells/tissues that are released into the circulating blood stream and any changes in their level because of pathological conditions may be used as markers in disease diagnosis. Raman spectroscopy has been exploited to characterize the biomolecules present in the blood plasma of clinically confirmed normal group, premalignant (Oral Sub Mucous Fibrosis) and malignant (Oral Squamous Cell Carcinoma) at 784.15nm. Raman spectral signatures show relatively less intense Raman bands of phenylalanine, lipid and antioxidant beta carotene but higher intense bands for proteins, DNA base components and amino acids (tyrosine and tryptophan) for malignant group than that of normal group. However premalignant group possess high intense Raman bands for amino acids (tyrosine and tryptophan) at 830, 1020 and 1620 cm(-1) and protein peaks at 913, 978 and 1646 cm(-1) when compared to that of malignant and normal group. Principal component analysis coupled with linear discriminant analysis (PCA-LDA) yielded a diagnostic sensitivity of 96.3% and 91.2%, and a specificity of 80.0% and 96.7% in the classification of normal from premalignant and normal from malignant, respectively. This indicates that Raman spectroscopy of blood plasma has the potential in classifying normal and oral malignancy conditions. Copyright (C) 2015 JohnWiley & Sons, Ltd.
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页码:735 / 743
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Verma S.P., 1989, United States Patent, Patent No. 4832483
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Yuvaraj, Manoharan
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Udayakumar, Kanniyappan
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Udayakumar, Kanniyappan
;
Jayanth, Vadivel
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Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Madras 600095, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Jayanth, Vadivel
;
Rao, Aruna Prakasa
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Rao, Aruna Prakasa
;
Bharanidharan, Ganesan
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Bharanidharan, Ganesan
;
Koteeswaran, Dornadula
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Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Madras 600095, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Koteeswaran, Dornadula
;
Munusamy, Balu David
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Govt Arignar Anna Mem Canc Hosp, Karapettai 631501, Kanchipuram, India
Reg Canc Ctr, Karapettai 631501, Kanchipuram, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Munusamy, Balu David
;
Krishna, Chilakapati Murali
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Tata Mem Hosp, ACTREC, Navi Mumbai 410210, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Krishna, Chilakapati Murali
;
Ganesan, Singaravelu
论文数: 0引用数: 0
h-index: 0
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
机构:
Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Yuvaraj, Manoharan
;
Udayakumar, Kanniyappan
论文数: 0引用数: 0
h-index: 0
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Udayakumar, Kanniyappan
;
Jayanth, Vadivel
论文数: 0引用数: 0
h-index: 0
机构:
Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Madras 600095, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Jayanth, Vadivel
;
Rao, Aruna Prakasa
论文数: 0引用数: 0
h-index: 0
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Rao, Aruna Prakasa
;
Bharanidharan, Ganesan
论文数: 0引用数: 0
h-index: 0
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Bharanidharan, Ganesan
;
Koteeswaran, Dornadula
论文数: 0引用数: 0
h-index: 0
机构:
Meenakshi Ammal Dent Coll & Hosp, Dept Oral Med & Radiol, Madras 600095, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Koteeswaran, Dornadula
;
Munusamy, Balu David
论文数: 0引用数: 0
h-index: 0
机构:
Govt Arignar Anna Mem Canc Hosp, Karapettai 631501, Kanchipuram, India
Reg Canc Ctr, Karapettai 631501, Kanchipuram, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Munusamy, Balu David
;
Krishna, Chilakapati Murali
论文数: 0引用数: 0
h-index: 0
机构:
Tata Mem Hosp, ACTREC, Navi Mumbai 410210, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India
Krishna, Chilakapati Murali
;
Ganesan, Singaravelu
论文数: 0引用数: 0
h-index: 0
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Anna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, IndiaAnna Univ, Dept Med Phys, Madras 600025, Tamil Nadu, India