Diastereoselective Synthesis of Novel and Enantiopure Tetrahy-dropyrano[3,2-c]quinolines

被引：5

作者：

Moshapo, Paseka T. ^{[1
]}

Kinfe, Henok H. ^{[1
]}

机构：

[1] Univ Johannesburg, Dept Chem, Auckland Pk, South Africa

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 23期

关键词：

tetrahydropyrano[3; 2-c]quinoline; Friedel-Crafts alkylation; Povarov reaction; glucal; scandium triflate; DIELS-ALDER REACTIONS; STEREOSELECTIVE-SYNTHESIS; ARYL AMINES; PHENANTHROLINE DERIVATIVES; EFFICIENT SYNTHESIS; TETRAHYDROQUINOLINES; CYCLIZATION; THIOCHROMANS; ALDEHYDES; GLYCALS;

D O I：

10.1055/s-0035-1560174

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective synthesis of novel and enantiopure N-alkylated tetrahydropyrano[3,2-c]quinolines is described via intramolecular Friedel-Crafts alkylation using a 1-O-acetylglucosyl derivative as the key intermediate. Unprecedented formation of new glycal derivatives and ,-unsaturated carbaldehyde products is also discussed.

引用

页码：3673 / 3686

页数：14

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