Rh(I)-catalyzed regio- and enantioselective allylic alkylation of Meldrum's acid

被引：16

作者：

Liu, Min ^{[1
]}

Zhao, Haiying ^{[1
]}

Li, Changkun ^{[2
]}

机构：

[1] Inner Mongolia Univ, Coll Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Rhodium; Bisoxazolinephosphine; Allylic substitution; Meldrum's acid; Asymmetric catalysis;

D O I：

10.1016/j.cclet.2020.04.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rh(I)-catalyzed highly regio- and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed. The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities. This method provides a rapid access to various chiral beta-alkyl-gamma,delta-unsaturated carboxylic acids and their derivatives. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：385 / 388

页数：4

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