The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

被引：10

作者：

Liu, Ting ^{[1
]}

Kong, Wei-xia ^{[2
]}

Tang, Xiao-yi ^{[2
]}

Xu, Man ^{[1
]}

Wang, Qing-han ^{[1
]}

Zhang, Bin ^{[2
]}

Hu, Liang-ding ^{[1
]}

Chen, Hu ^{[1
]}

机构：

[1] Acad Mil Med Sci, Dept Hematopoiet Stem Cell Transplantat, Beijing 100071, Peoples R China

[2] Acad Mil Med Sci, Cell & Gene Therapy Ctr, Beijing 100071, Peoples R China

来源：

CELL DEATH & DISEASE | 2018年 / 9卷

基金：

国家高技术研究发展计划(863计划);

关键词：

BONE-MARROW; MULTILINEAGE DIFFERENTIATION; GENE-EXPRESSION; IN-VIVO; PROLIFERATION; MAINTENANCE; ACTIVATION; HOXA9; REPOPULATION; PROGENITORS;

D O I：

10.1038/s41419-018-0721-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematopoietic stem cells (HSCs) can give rise to all blood cells that are essential to defend against pathogen invasion. The defective capability of HSC self-renewal is linked to many serious diseases, such as anemia. However, the potential mechanism regulating HSC self-renewal has not been thoroughly elucidated to date. In this study, we showed that Zfp90 was highly expressed in HSCs. Zfp90 deficiency in the hematopoietic system caused impaired HSPC pools and led to HSC dysfunction. We showed that Zfp90 deletion inhibited HSC proliferation, while HSC apoptosis was not affected. Regarding the mechanism of this effect on HSC proliferation, we found that Zfp90 interacted with Snf2l, a subunit of the NURF complex, to regulate Hoxa9 expression. Ectopic expression of Hoxa9 rescued the HSC repopulation capacity in Zfp90-deficient mice, which indicates that Hoxa9 is the downstream effector of Zfp90. In summary, our findings identify Zfp90 as a key transcription factor in determining the fate of HSCs.

引用

页数：12

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[11] GATA-3 regulates the self-renewal of long-term hematopoietic stem cells [J].

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Stevens, Brett M. ;

Jones, Courtney L. ;

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Jordan, Craig T. .

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[18] Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential [J].

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Woehrer, Stefan ;

Dykstra, Brad J. ;

Ma, Elaine ;

Cheyne, John ;

Zhao, Yongjun ;

Bowie, Michelle B. ;

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Eaves, Connie J. .

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