Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction

被引：9
作者：
Bick, Sarah K. B. [1 ,2 ]
Folley, Bradley S. [1 ,3 ]
Mayer, Jutta S. [4 ,5 ]
Park, Sohee [4 ]
Charles, P. David [6 ]
Camalier, Corrie R. [1 ]
Pallavaram, Srivatsan [7 ]
Konrad, Peter E. [1 ]
Neimat, Joseph S. [1 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Neurosurg, Nashville, TN USA
[2] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
[3] Norton Neurosci Inst, Louisville, KY USA
[4] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA
[5] Goethe Univ Frankfurt, Dept Psychol, Frankfurt, Germany
[6] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN USA
[7] Vanderbilt Univ, Dept Elect Engn & Comp Sci, 221 Kirkland Hall, Nashville, TN 37235 USA
来源：
NEUROMODULATION | 2017年 / 20卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Deep brain stimulation; emotion; near infrared spectroscopy; Parkinson's disease; subthalamic nucleus; NEAR-INFRARED SPECTROSCOPY; PARKINSONS-DISEASE; FOLLOW-UP; RECOGNITION; MOOD; EXPERIENCE; REGION; TRIAL; ACTIVATION; CORTEX;
D O I：
10.1111/ner.12537
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
ObjectivesDeep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. Materials and MethodsWe used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation-on and stimulation-off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states. ResultsDeep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli. ConclusionsThese results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
引用
收藏
页码：233 / 237
页数：5
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