Theoretical and experimental study of mutations induced by 8-oxoguanine

被引：0
作者：
Vasyunina, E. A. [1 ]
Rogozin, I. B. [1 ]
Sinitsina, O., I [1 ]
Plaksina, A. S. [1 ]
Rotskaya, U. N. [1 ]
机构：
[1] SB RAS, Inst Cytol & Genet, Novosibirsk, Russia
来源：
Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, Vol 1 | 2004年
关键词：
oxidative mutagenesis; evolutionary conservation; DNA context; hotspots;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Motivation: The process of mutation is fundamental in biology, being an essential evolutionary factor that creates genetic variation. Understanding complex mechanisms by which mutations occur spontaneously or are induced by mutagens is an important goal of molecular biology. Results: We analyzed mutations induced by 8-oxoguanine (8-oxoG) using various computational techniques. Results suggested that mutagenesis due to 8-oxoG is significantly influenced by nearest neighboring bases and the context is quite evolutionarily stable. The revealed context properties might reflect intrinsic properties of interactions between 8-oxoG and DNA. Comparative analysis of spontaneous mutations suggested that a substantial fraction of spontaneous A center dot T -> C center dot T mutations is caused by 8-oxoGTP in nucleotide pools.
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页码：200 / 203
页数：4
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