Effect of High Perioperative Oxygen Fraction on Surgical Site Infection and Pulmonary Complications After Abdominal Surgery The PROXI Randomized Clinical Trial

被引：299

作者：

Meyhoff, Christian S.

Wetterslev, Jorn ^{[2
]}

Jorgensen, Lars N. ^{[4
]}

Henneberg, Steen W.

Hogdall, Claus ^{[3
]}

Lundvall, Lene ^{[3
]}

Svendsen, Poul-Erik ^{[5
]}

Mollerup, Hannah ^{[5
]}

Lunn, Troels H. ^{[5
]}

Simonsen, Inger ^{[4
]}

Martinsen, Kristian R. ^{[6
]}

Pulawska, Therese ^{[7
]}

Bundgaard, Lars ^{[7
]}

Bugge, Lasse ^{[7
]}

Hansen, Egon G. ^{[8
]}

Riber, Claus ^{[9
]}

Gocht-Jensen, Peter ^{[9
]}

Walker, Line R. ^{[9
]}

Bendtsen, Asger

Johansson, Gun

Skovgaard, Nina ^{[10
]}

Helto, Kim ^{[11
]}

Poukinski, Andrei ^{[11
]}

Korshin, Andre ^{[12
]}

Walli, Aqil ^{[12
]}

Bulut, Mustafa ^{[13
]}

Carlsson, Palle S. ^{[14
]}

Rodt, Svein A. ^{[14
]}

Lundbech, Liselotte B. ^{[14
]}

Rask, Henrik ^{[15
]}

Buch, Niels ^{[16
]}

Perdawid, Sharafaden K. ^{[17
]}

Reza, Joan ^{[17
]}

Jensen, Kirsten V. ^{[18
]}

Carlsen, Charlotte G. ^{[19
]}

Jensen, Frank S. ^{[20
]}

Rasmussen, Lars S. ^{[1
]}

机构：

[1] Rigshosp, Copenhagen Univ Hosp, Ctr Head & Orthopaed, Juliane Marie Ctr,Dept Anaesthesia,Sect 4231, DK-2100 Copenhagen, Denmark

[2] Rigshosp, Copenhagen Univ Hosp, Juliane Marie Ctr, Copenhagen Trial Unit,Ctr Clin Intervent Res, DK-2100 Copenhagen, Denmark

[3] Rigshosp, Copenhagen Univ Hosp, Juliane Marie Ctr, Dept Gynaecol, DK-2100 Copenhagen, Denmark

[4] Univ Copenhagen, Bispebjerg Hosp, Dept Surg, Copenhagen, Denmark

[5] Univ Copenhagen, Bispebjerg Hosp, Dept Anaesthesia, Copenhagen, Denmark

[6] Vejle Hosp, Dept Anaesthesia, Veijle, Denmark

[7] Vejle Hosp, Dept Surg, Veijle, Denmark

[8] Copenhagen Univ Hosp, Dept Anaesthesia, Herlev, Denmark

[9] Copenhagen Univ Hosp, Dept Surg, Herlev, Denmark

[10] Rigshosp, Copenhagen Univ Hosp, Dept Surg, DK-2100 Copenhagen, Denmark

[11] Nykobing Falster Hosp, Dept Anaesthesia, Nykobing, Denmark

[12] Slagelse Hosp, Dept Anaesthesia, Slagelse, Denmark

[13] Slagelse Hosp, Dept Surg, Slagelse, Denmark

[14] Aarhus Univ Hosp, Dept Anaesthesiol, DK-8000 Aarhus, Denmark

[15] Odense Univ Hosp, Dept Anaesthesiol, Svendborg, Denmark

[16] Odense Univ Hosp, Dept Surg, Svendborg, Denmark

[17] Naestved Hosp, Dept Surg, Naestved, Denmark

[18] Viborg Hosp, Dept Anaesthesia, Viborg, Denmark

[19] Viborg Hosp, Dept Surg, Viborg, Denmark

[20] Copenhagen Univ Hosp, Dept Anaesthesia, Gentofte, Denmark

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2009年 / 302卷 / 14期

基金：

英国医学研究理事会;

关键词：

WOUND-INFECTION; SUPPLEMENTAL OXYGEN; POSTOPERATIVE NAUSEA; NITROUS-OXIDE; RISK; HYPEROXIA; INDEX; PREVENTION; REDUCE;

D O I：

10.1001/jama.2009.1452

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context Use of 80% oxygen during surgery has been suggested to reduce the risk of surgical wound infections, but this effect has not been consistently identified. The effect of 80% oxygen on pulmonary complications has not been well defined. Objective To assess whether use of 80% oxygen reduces the frequency of surgical site infection without increasing the frequency of pulmonary complications in patients undergoing abdominal surgery. Design, Setting, and Patients The PROXI trial, a patient-and observer-blinded randomized clinical trial conducted in 14 Danish hospitals between October 2006 and October 2008 among 1400 patients undergoing acute or elective laparotomy. Interventions Patients were randomly assigned to receive either 80% or 30% oxygen during and for 2 hours after surgery. Main Outcome Measures Surgical site infection within 14 days, defined according to the Centers for Disease Control and Prevention. Secondary outcomes included atelectasis, pneumonia, respiratory failure, and mortality. Results Surgical site infection occurred in 131 of 685 patients (19.1%) assigned to receive 80% oxygen vs 141 of 701 (20.1%) assigned to receive 30% oxygen (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.72-1.22; P=.64). Atelectasis occurred in 54 of 685 patients (7.9%) assigned to receive 80% oxygen vs 50 of 701 (7.1%) assigned to receive 30% oxygen (OR, 1.11; 95% CI, 0.75-1.66; P=.60), pneumonia in 41 (6.0%) vs 44 (6.3%) (OR, 0.95; 95% CI, 0.61-1.48; P=.82), respiratory failure in 38 (5.5%) vs 31 (4.4%) (OR, 1.27; 95% CI, 0.78-2.07; P=.34), and mortality within 30 days in 30 (4.4%) vs 20 (2.9%) (OR, 1.56; 95% CI, 0.88-2.77; P=.13). Conclusion Administration of 80% oxygen compared with 30% oxygen did not result in a difference in risk of surgical site infection after abdominal surgery. Trial Registration clinicaltrials.gov Identifier: NCT00364741 JAMA. 2009; 302(14): 1543-1550

引用

页码：1543 / 1550

页数：8

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