Virus-like particles: Passport to immune recognition

被引：464

作者：

Grgacic, Elizabeth V. L. ^{[1
]}

Anderson, David A. ^{[1
]}

机构：

[1] MacFarlane Burnet Inst Med Res & Publ Hlth, Melbourne, Vic 3004, Australia

来源：

METHODS | 2006年 / 40卷 / 01期

关键词：

virus-like particles; vaccine; chimeric VLPs;

D O I：

10.1016/j.ymeth.2006.07.018

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. In many cases such VLPs have structural characteristics and antigenicity similar to the parental virus, and some have already proven successful as vaccines against the cognate virus infection. The structural components of some VLPs have also proven amenable to the insertion or fusion of foreign antigenic sequences, allowing the production of chimeric VLPs exposing the foreign antigen on their surface. Other VLPs have been used as carriers for foreign antigens, including non-protein antigens, via chemical conjugation. This review outlines some of the advantages, disadvantages, and technical considerations for the use of a wide range of VLP systems in vaccine development. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：60 / 65

页数：6

共 90 条

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