Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

被引：83

作者：

Kim, Min Hwan ^{[1
]}

Kim, Joon ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, 291 Daehak Ro, Taejon 34141, South Korea

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Drug; Resistance; YAP; TAZ; Hippo pathway; Biomarker; YES-ASSOCIATED PROTEIN; HIPPO TRANSDUCER TAZ; AMPK-MEDIATED REGULATION; GENOME-WIDE ASSOCIATION; CANCER DRUG-RESISTANCE; ORGAN SIZE CONTROL; CELL-CYCLE EXIT; TUMOR-SUPPRESSOR; STEM-CELLS; LUNG ADENOCARCINOMA;

D O I：

10.1007/s00018-016-2412-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A diverse range of drug resistance mechanisms in cancer cells and their microenvironment significantly reduces the effectiveness of anti-cancer therapies. Growing evidence suggests that transcriptional effectors of the Hippo pathway, YAP and TAZ, promote resistance to various anti-cancer therapies, including cytotoxic chemotherapy, molecular targeted therapy, and radiation therapy. Here, we overview the role of YAP and TAZ as drug resistance mediators, and also discuss potential upstream regulators and downstream targets of YAP/TAZ in cancer. The widespread involvement of YAP and TAZ in resistance mechanisms suggests that therapeutic targeting of YAP and TAZ may expedite the development of effective anti-resistance therapies.

引用

页码：1457 / 1474

页数：18

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