Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

被引：584

作者：

Soderling, SH ^{[1
]}

Beavo, JA ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)00073-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered and characterized. In addition, several new highly specific PDE inhibitors have been developed and approved for clinical use. Finally, new strategies have been employed to determine PDE function in model systems including the use of antisense oligonucleotide and disruption techniques.

引用

页码：174 / 179

页数：6

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