NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer

被引：25
作者：
Gai, Long-Xian [1 ]
Wang, Wei-Qing [2 ]
Wu, Xia [1 ]
Su, Xiu-Jun [1 ]
Yang, Fu-Cun [3 ]
机构：
[1] Third Peoples Hosp Linyi, Dept Radiotherapy, Linyi, Shandong, Peoples R China
[2] Third Peoples Hosp Linyi, Dept Radiol, Linyi, Shandong, Peoples R China
[3] Linyi Canc Hosp, Dept Radiotherapy, 6 Lingyuan East St, Linyi 276000, Shandong, Peoples R China
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2019年 / 194卷
关键词：
(OE-19); Photothermal therapy; RNGO; Nano-graphene oxide; PEGYLATED NANOGRAPHENE OXIDE; SILVER NANOPARTICLES; GREEN SYNTHESIS; REDUCTION; SIZE; DELIVERY; CHEMISTRY; QUALITY; SHEETS;
D O I：
10.1016/j.jphotobiol.2019.03.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Theranostic agents were drawing a huge attention in the personalized medication. In this study, we established a facile technique, plant extract-based technique for the synthesis of reduced nano-graphene oxide (RNGO) with low cytotoxicity. We formed platforms of photothermal (PT) therapy and further explained that the synthesized RNGO can be utilized as ready to use PT therapy without any additional surface adjustment. In the meantime, with the help of a constant-wave NIR laser (near-infrared), in vitro esophageal adenocarcinoma cell line (OE-19) cancer cells were effectively ablated, because of the PT impact of RNGO. The outcomes propose that the RNGO was appropriate for PT therapy and photoacoustic imaging of the tumor, which is assuring for theranostic nanomedicine.
引用
收藏
页码：188 / 193
页数：6
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