NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer

被引：25

作者：

Gai, Long-Xian ^{[1
]}

Wang, Wei-Qing ^{[2
]}

Wu, Xia ^{[1
]}

Su, Xiu-Jun ^{[1
]}

Yang, Fu-Cun ^{[3
]}

机构：

[1] Third Peoples Hosp Linyi, Dept Radiotherapy, Linyi, Shandong, Peoples R China

[2] Third Peoples Hosp Linyi, Dept Radiol, Linyi, Shandong, Peoples R China

[3] Linyi Canc Hosp, Dept Radiotherapy, 6 Lingyuan East St, Linyi 276000, Shandong, Peoples R China

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2019年 / 194卷

关键词：

(OE-19); Photothermal therapy; RNGO; Nano-graphene oxide; PEGYLATED NANOGRAPHENE OXIDE; SILVER NANOPARTICLES; GREEN SYNTHESIS; REDUCTION; SIZE; DELIVERY; CHEMISTRY; QUALITY; SHEETS;

D O I：

10.1016/j.jphotobiol.2019.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Theranostic agents were drawing a huge attention in the personalized medication. In this study, we established a facile technique, plant extract-based technique for the synthesis of reduced nano-graphene oxide (RNGO) with low cytotoxicity. We formed platforms of photothermal (PT) therapy and further explained that the synthesized RNGO can be utilized as ready to use PT therapy without any additional surface adjustment. In the meantime, with the help of a constant-wave NIR laser (near-infrared), in vitro esophageal adenocarcinoma cell line (OE-19) cancer cells were effectively ablated, because of the PT impact of RNGO. The outcomes propose that the RNGO was appropriate for PT therapy and photoacoustic imaging of the tumor, which is assuring for theranostic nanomedicine.

引用

页码：188 / 193

页数：6

共 36 条

[1] The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy [J].

Akhavan, Omid ;

Ghaderi, Elham ;

Aghayee, Samira ;

Fereydooni, Yasamin ;

Talebi, Ali .

JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (27) :13773-13781

[2] One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery [J].

Chen, Jingqin ;

Liu, Hongyu ;

Zhao, Chubiao ;

Qin, Guiqi ;

Xi, Gaina ;

Li, Tan ;

Wang, Xiaoping ;

Chen, Tongsheng .

BIOMATERIALS, 2014, 35 (18) :4986-4995

[3] Facile and green reduction of covalently PEGylated nanographene oxide via a 'water-only' route for high-efficiency photothermal therapy [J].

Chen, Jingqin ;

Wang, Xiaoping ;

Chen, Tongsheng .

NANOSCALE RESEARCH LETTERS, 2014, 9

[4] Mass-production of highly-crystalline few-layer graphene sheets by arc discharge in various H2-inert gas mixtures [J].

Chen, Yani ;

Zhao, Hongbin ;

Sheng, Leimei ;

Yu, Liming ;

An, Kang ;

Xu, Jiaqiang ;

Ando, Yoshinori ;

Zhao, Xinluo .

CHEMICAL PHYSICS LETTERS, 2012, 538 :72-76

[5] Chemical reduction of graphene oxide: a synthetic chemistry viewpoint [J].

Chua, Chun Kiang ;

Pumera, Martin .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (01) :291-312

[6] New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide [J].

Feng, Lingyan ;

Wu, Li ;

Qu, Xiaogang .

ADVANCED MATERIALS, 2013, 25 (02) :168-186

[7] Interpretation of Raman spectra of disordered and amorphous carbon [J].

Ferrari, AC ;

Robertson, J .

PHYSICAL REVIEW B, 2000, 61 (20) :14095-14107

[8] Probing the Thermal Deoxygenation of Graphene Oxide Using High-Resolution In Situ X-ray-Based Spectroscopies [J].

Ganguly, Abhijit ;

Sharma, Surbhi ;

Papakonstantinou, Pagona ;

Hamilton, Jeremy .

JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (34) :17009-17019

[9] Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene [J].

Jiang, Tianyue ;

Sun, Wujin ;

Zhu, Qiuwen ;

Burns, Nancy A. ;

Khan, Saad A. ;

Mo, Ran ;

Gu, Zhen .

ADVANCED MATERIALS, 2015, 27 (06) :1021-1028

[10] A Raman spectroscopic investigation of graphite oxide derived graphene [J].

Kaniyoor, Adarsh ;

Ramaprabhu, Sundara .

AIP ADVANCES, 2012, 2 (03)

← 1 2 3 4 →