Infections and cancer: Established associations and new hypotheses

被引:171
作者
de Martel, Catherine [1 ]
Franceschi, Silvia [1 ]
机构
[1] Int Agcy Res Canc, F-69372 Lyon 08, France
关键词
Infection; Cancer; Risk factor; Helicobacter pylori; Hepatitis B virus; Hepatitis C virus; Human papilloma virus; Epidemiology; EPSTEIN-BARR-VIRUS; HEPATITIS-C VIRUS; HUMAN-PAPILLOMAVIRUS INFECTION; NON-HODGKINS-LYMPHOMA; T-CELL LEUKEMIA; HELICOBACTER-PYLORI ERADICATION; SARCOMA-ASSOCIATED HERPESVIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; INVASIVE CERVICAL-CANCER; HEPATOCELLULAR-CARCINOMA;
D O I
10.1016/j.critrevonc.2008.07.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Around the world, infection is one of the most important causes of cancer. Almost one in every five malignancies can be attributed to infectious agents. Among infection-related neoplasms, cancers of the stomach, liver and cervix uteri detain the highest incidence figures, and are known to be largely attributable to Helicobacter pylori, hepatitis B and C viruses, and human papilloma virus, respectively. Other infectious organisms can also cause cancer; these include the Epstein-Barr virus (nasopharyngeal carcinoma, and different types of lymphoma), Human herpes virus-8 (Kaposi's Sarcoma), human T-cell leukemia virus type I (leukaemia, lymphoma), liver flukes (cholangiocarcinoma) and schistosomiasis (bladder cancer). Infection with human immunodeficiency virus, although strongly associated with an excess of cancer incidence at many cancer sites, is probably not carcinogenic per se, but acts mainly via immunodeficiency. The burden of infection-related cancers is still underestimated worldwide, due to the use of conservative population prevalence and risk ratio estimates. Furthermore, associations with new infectious agents remain yet to be explored. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:183 / 194
页数:12
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