Comparison of CT, PET, and PET/CT for Staging of Patients with Indolent Non-Hodgkin's Lymphoma

被引：49
作者：
Fueger, Barbara J. [1 ]
Yeom, Kristen [2 ]
Czernin, Johannes [1 ]
Sayre, James W. [2 ]
Phelps, Michael E. [1 ]
Allen-Auerbach, Martin S. [1 ,3 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Nucl Med, Los Angeles, CA 90095 USA
来源：
MOLECULAR IMAGING AND BIOLOGY | 2009年 / 11卷 / 04期
关键词：
PET; PET/CT; Indolent lymphoma; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED-TOMOGRAPHY; DIAGNOSTIC-ACCURACY; MALIGNANT-LYMPHOMA; FDG-PET/CT; THERAPY; DISEASE; SCAN; BRONCHIOLOALVEOLAR; RITUXIMAB;
D O I：
10.1007/s11307-009-0200-9
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The aim was to investigate the potential impact of positron emission tomography (PET)/computed tomography (CT) as compared to PET and CT on the staging of patients with indolent lymphoma. PET/CTs from 45 patients with indolent lymphoma undergoing staging or restaging were studied. Clinical follow-up, additional imaging, and histology served as the gold standard. PET/CT correctly diagnosed 92 nodal regions as positive for lymphomatous involvement and 458 as disease free vs 68 and 449 for PET and 64 and 459 for CT, respectively. The respective sensitivities, specificities, and accuracies were 99%, 100%, and 99.8% for PET/CT, 68%, 97.5%, and 92.2% for PET, and 70%, 100%, and 94.7% for CT. PET/CT performed significantly better than PET (p < 0.001 for sensitivity, specificity, and accuracy) and CT (p < 0.001 for sensitivity and accuracy). PET/CT also correctly identified significantly more extra-nodal lesions (22) than CT (14) and PET (nine). PET/CT provides significantly more accurate information compared to PET and CT for the staging and re-staging of patients with indolent lymphoma.
引用
收藏
页码：269 / 274
页数：6
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