Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

被引：121

作者：

Jenwitheesuk, Anorut ^{[1
]}

Nopparat, Chutikorn ^{[1
]}

Mukda, Sujira ^{[1
]}

Wongchitrat, Prapimpun ^{[2
]}

Govitrapong, Piyarat ^{[1
,3
,4
]}

机构：

[1] Mahidol Univ, Inst Mol Biosci, Res Ctr Neurosci, Salaya 73170, Nakornpathom, Thailand

[2] Mahidol Univ, Fac Med Technol, Ctr Innovat Dev & Technol Transfer, Salaya 73170, Nakornpathom, Thailand

[3] Mahidol Univ, Fac Sci, Ctr Neurosci, Bangkok 10400, Thailand

[4] Mahidol Univ, Fac Sci, Dept Pharmacol, Bangkok 10400, Thailand

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期

关键词：

melatonin; brain aging; energy metabolism; epigenetics; autophagy; circadian rhythm; neurodegeneration; sirtuins; NF-KAPPA-B; GROWTH-FACTOR-I; CLOCK GENE-EXPRESSION; AGE-INDUCED ALTERATIONS; IKK-BETA SUPPRESSION; LIFE-SPAN; ALZHEIMERS-DISEASE; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION FACTOR; CALORIE RESTRICTION;

D O I：

10.3390/ijms150916848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.

引用

页码：16848 / 16884

页数：37

共 50 条

[41] Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways [J].

Fan, Rui ;

Zhang, Ying ;

Liu, Rui ;

Wei, Chan ;

Wang, Xiujuan ;

Wu, Xin ;

Yu, Xiaochen ;

Li, Zhen ;

Mao, Ruixue ;

Hu, Jiani ;

Zhu, Na ;

Liu, Xinran ;

Li, Yong ;

Xu, Meihong .

NUTRIENTS, 2024, 16 (12)

[42] Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration [J].

Gudenschwager, Camila ;

Chavez, Isadora ;

Cardenas, Cesar ;

Gonzalez-Billault, Christian .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021

[43] p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene [J].

He, Z. ;

Liu, H. ;

Agostini, M. ;

Yousefi, S. ;

Perren, A. ;

Tschan, M. P. ;

Mak, T. W. ;

Melino, G. ;

Simon, H. U. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (10) :1415-1424

[44] p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene [J].

Z He ;

H Liu ;

M Agostini ;

S Yousefi ;

A Perren ;

M P Tschan ;

T W Mak ;

G Melino ;

H U Simon .

Cell Death & Differentiation, 2013, 20 :1415-1424

[45] Helicobacter pylori regulates ILK to influence autophagy through Rac1 and RhoA signaling pathways in gastric epithelial cells [J].

Xu, Zheng ;

Li, Boqing ;

Du, Yunqiu ;

Zhang, Ruiqing ;

Tong, Xiaohan ;

Li, Jing ;

Wu, Yulong ;

Ji, Xiaofei ;

Zhang, Ying .

MICROBIAL PATHOGENESIS, 2021, 158

[46] Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells [J].

Yan, Xiaoyu ;

Qu, Xianzhi ;

Liu, Buhan ;

Zhao, Yuanxin ;

Xu, Long ;

Yu, Sihang ;

Wang, Jian ;

Wang, Liying ;

Su, Jing .

FRONTIERS IN ONCOLOGY, 2021, 11

[47] AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy [J].

Chen, Ming ;

Liu, Jiaxing ;

Yang, Lili ;

Ling, Wenhua .

FEBS OPEN BIO, 2017, 7 (06) :811-820

[48] Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways [J].

Cao, Li ;

Zhang, Xinyan ;

Yuan, Sumei ;

Cheng, Kai ;

Zhang, Xiaoyan .

MICROBIAL PATHOGENESIS, 2019, 131 :120-127

[49] Chlorpyrifos induced autophagy and mitophagy in common carp livers through AMPK pathway activated by energy metabolism disorder [J].

Cui, Jiawen ;

Hao, Zhiyu ;

Zhou, Qin ;

Qiu, Minna ;

Liu, Yuhang ;

Liu, Yuhao ;

Teng, Xiaohua ;

Kang, Lu .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 258

[50] AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy [J].

Dong, H. -W. ;

Zhang, L. -F. ;

Bao, S. -L. .

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 22 (09) :2757-2766

← 1 2 3 4 5 →