Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

被引：122

作者：

Jenwitheesuk, Anorut ^{[1
]}

Nopparat, Chutikorn ^{[1
]}

Mukda, Sujira ^{[1
]}

Wongchitrat, Prapimpun ^{[2
]}

Govitrapong, Piyarat ^{[1
,3
,4
]}

机构：

[1] Mahidol Univ, Inst Mol Biosci, Res Ctr Neurosci, Salaya 73170, Nakornpathom, Thailand

[2] Mahidol Univ, Fac Med Technol, Ctr Innovat Dev & Technol Transfer, Salaya 73170, Nakornpathom, Thailand

[3] Mahidol Univ, Fac Sci, Ctr Neurosci, Bangkok 10400, Thailand

[4] Mahidol Univ, Fac Sci, Dept Pharmacol, Bangkok 10400, Thailand

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期

关键词：

melatonin; brain aging; energy metabolism; epigenetics; autophagy; circadian rhythm; neurodegeneration; sirtuins; NF-KAPPA-B; GROWTH-FACTOR-I; CLOCK GENE-EXPRESSION; AGE-INDUCED ALTERATIONS; IKK-BETA SUPPRESSION; LIFE-SPAN; ALZHEIMERS-DISEASE; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION FACTOR; CALORIE RESTRICTION;

D O I：

10.3390/ijms150916848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.

引用

页码：16848 / 16884

页数：37

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