25-Hydroxycholesterols in innate and adaptive immunity

被引:264
作者
Cyster, Jason G. [1 ,2 ]
Dang, Eric V. [1 ]
Reboldi, Andrea [1 ]
Yi, Tangsheng [1 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[3] Genentech Inc, Dept Discovery Immunol, San Francisco, CA 94080 USA
基金
美国国家卫生研究院;
关键词
EPSTEIN-BARR-VIRUS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; A REDUCTASE-ACTIVITY; B-CELL MIGRATION; ROR-GAMMA-T; OXYSTEROL-BINDING; RECEPTOR EBI2; 7-TRANSMEMBRANE RECEPTOR; CHOLESTEROL-BIOSYNTHESIS; STRUCTURAL MOTIFS;
D O I
10.1038/nri3755
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory influences. In addition, a dihydroxylated form of cholesterol functions as an immune cell guidance cue by engaging the G protein-coupled receptor EBI2, and it is required for mounting adaptive immune responses. In this Review, we summarize the current understanding of the closely related oxysterols 25-hydroxycholesterol and 7 alpha, 25-dihydroxycholesterol, and the growing evidence that they have wide-ranging influences on innate and adaptive immunity.
引用
收藏
页码:731 / 743
页数:13
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