The interactome challenge

被引：10
作者：
Aitchison, John D. [1 ,2 ]
Rout, Michael P. [3 ]
机构：
[1] Ctr Infect Dis Res, Seattle, WA 98109 USA
[2] Inst Syst Biol, Seattle, WA 98109 USA
[3] Rockefeller Univ, Lab Cellular & Struct Biol, New York, NY 10065 USA
来源：
JOURNAL OF CELL BIOLOGY | 2015年 / 211卷 / 04期
关键词：
D O I：
10.1083/jcb.201510108
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beginning to be met.
引用
收藏
页码：729 / 732
页数：4
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