Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

被引：20

作者：

Farshidpour, Maham ^{[1
]}

Ahmed, Monjur ^{[2
]}

Junna, Shilpa ^{[3
]}

Merchant, Juanita L. ^{[3
]}

机构：

[1] Banner Univ, Med Ctr, Inpatient Med, 1501 N Campbell Ave, Tucson, AZ 85724 USA

[2] Thomas Jefferson Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Philadelphia, PA 19107 USA

[3] Banner Univ, Med Ctr, Div Gastroenterol & Hepatol, Tucson, AZ 85724 USA

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2021年 / 13卷 / 01期

关键词：

Myeloid-derived suppressor cells; Gastrointestinal cancers; Immune checkpoint inhibitors; Tumor progression; REGULATORY T-CELLS; GASTRIC-CANCER; TUMOR MICROENVIRONMENT; DENDRITIC CELLS; CARCINOMA; CHEMOTHERAPY; PROGRESSION; INFLAMMATION; INHIBITION; ESOPHAGEAL;

D O I：

10.4251/wjgo.v13.i1.1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

引用

页码：1 / 11

页数：11

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