Speciation analysis of organotin compounds in human urine by headspace solid-phase micro-extraction and gas chromatography with pulsed flame photometric detection

被引：16
作者：
Valenzuela, Anibal [1 ]
Lespes, Gaetane [2 ]
Quiroz, Waldo [1 ]
Aguilar, Luis F. [3 ]
Bravo, Manuel A. [1 ]
机构：
[1] Pontificia Univ Catolica Valparaiso, Inst Quim, Lab Quim Analit & Ambiental, Valparaiso, Chile
[2] Univ Pau & Pays Adour, IPREM, Lab Chim Analyt Bio Inorgan & Environm, F-64013 Pau, France
[3] Pontificia Univ Catolica Valparaiso, Inst Quim, Lab Fotofis & Espect Mol, Valparaiso, Chile
来源：
TALANTA | 2014年 / 125卷
关键词：
Organotin speciation; Headspace solid-phase micro-extraction (HS-SPME); Human urine; Storage conditions; Gas chromatography; Pulsed flame photometric detection (GC-PFPD); BUTYLTIN COMPOUNDS; HS-SPME; GC; MICROEXTRACTION; ENVIRONMENT; SAMPLES; WATERS; DERIVATIZATION; OPTIMIZATION; DEGRADATION;
D O I：
10.1016/j.talanta.2014.02.054
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new headspace solid-phase micro-extraction (HS-SPME) method followed by gas chromatography with pulsed flame photometric detection (GC-PFPD). analysis has been developed for the simultaneous determination of 11 organotin compounds, including methyl-, butyl-, phenyl- and octyltin derivates, in human urine. The methodology has been validated by the analysis of urine samples fortified with all analytes at different concentration levels, and recovery rates above 87% and relative precisions between 2% and 7% were obtained. Additionally, an experimental-design approach has been used to model the storage stability of organotin compounds in human urine, demonstrating that organotins are highly degraded in this medium, although their stability is satisfactory during the first 4 days of storage at 4 degrees C and pH=4. Finally, this methodology was applied to urine samples collected from harbor workers exposed to antifouling paints; methyl- and butyltins were detected, confirming human exposure in this type of work environment. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：196 / 203
页数：8
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