Targeting SIRT1 - a multitasker

被引：3

作者：

Davies, Shelley L. ^{[1
]}

Bozzo, Jordi ^{[1
]}

机构：

[1] Prous Sci, Barcelona 08080, Spain

来源：

DRUGS OF THE FUTURE | 2006年 / 31卷 / 05期

关键词：

D O I：

10.1358/dof.2006.031.05.982834

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The NAD(+)-dependent class III histone deacetylase SIRT1 modulates gene expression profiles in target tissues via regulation of transcriptional co-regulators; or by directly interacting with transcription factors. Different approaches to targeting SIRT1 can be applied therapeutically. SIRT1 activators show promise as therapies for obesity, diabetes, age-related diseases, Alzheimer's disease and stroke, while SIRT1 inhibition has been postulated for future cancer therapies and anti-HIV treatments. This article reviews the recent advances in SIRT1 research and identifies potential candidates for SIRT1-targeting therapeutics.

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页码：461 / 465

页数：5

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