A Chloroplast Retrograde Signal Regulates Nuclear Alternative Splicing

被引：172

作者：

Petrillo, Ezequiel ^{[1
]}

Godoy Herz, Micaela A. ^{[1
]}

Fuchs, Armin ^{[2
]}

Reifer, Dominik ^{[2
]}

Fuller, John ^{[3
]}

Yanovsky, Marcelo J. ^{[4
]}

Simpson, Craig ^{[3
]}

Brown, John W. S. ^{[3
,5
]}

Barta, Andrea ^{[2
]}

Kalyna, Maria ^{[2
]}

Kornblihtt, Alberto R. ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, Lab Fisiol & Biol Mol,IFIBYNE,CONICET, Buenos Aires, DF, Argentina

[2] Med Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

[3] James Hutton Inst, Dundee, Scotland

[4] Consejo Nacl Invest Cient & Tecn, Fdn Inst Leloir, IIBBA, RA-1033 Buenos Aires, DF, Argentina

[5] Univ Dundee, Div Plant Sci, James Hutton Inst, Dundee, Scotland

来源：

SCIENCE | 2014年 / 344卷 / 6182期

基金：

奥地利科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

GENE-EXPRESSION; ARABIDOPSIS; LIGHT; PROTEINS; TRANSCRIPTS; PLANTS;

D O I：

10.1126/science.1250322

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Light is a source of energy and also a regulator of plant physiological adaptations. We show here that light/dark conditions affect alternative splicing of a subset of Arabidopsis genes preferentially encoding proteins involved in RNA processing. The effect requires functional chloroplasts and is also observed in roots when the communication with the photosynthetic tissues is not interrupted, suggesting that a signaling molecule travels through the plant. Using photosynthetic electron transfer inhibitors with different mechanisms of action, we deduce that the reduced pool of plastoquinones initiates a chloroplast retrograde signaling that regulates nuclear alternative splicing and is necessary for proper plant responses to varying light conditions.

引用

页码：427 / 430

页数：4

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