BAG3 and HIF-1α Coexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation

被引：19
作者：
Xiao, Heng [1 ,2 ]
Tong, Rongliang [1 ,2 ]
Cheng, Shaobing [1 ,2 ]
Lv, Zhen [1 ]
Ding, Chaofeng [1 ]
Du, Chengli [1 ]
Xie, Haiyang [2 ]
Zhou, Lin [2 ]
Wu, Jian [2 ]
Zheng, Shusen [1 ,2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China
[2] Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou 310003, Zhejiang, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
关键词：
MESENCHYMAL TRANSITION; UP-REGULATION; CANCER-CELLS; PROTEIN; EXPRESSION; APOPTOSIS;
D O I：
10.1155/2014/516518
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective. The objective is to determine the effects of BAG3 and HIF-1 alpha expression on the prognosis of HCC patients after liver transplantation. Methods. Samples from 31 patients with HCC receiving liver transplantation were collected for this study. The immunohistochemistry was used to detect the expression of BAG3 and HIF-1 alpha of HCC samples. Results. According to the immunohistochemistry results, BAG3 and HIF-1 alpha staining were significantly associated with tumor TNM stage (P = 0.004,P = 0.012). A significant association between high BAG3/HIF-1 alpha levels and a shorter overall survival was detected, so as the combined BAG3 and HIF-1 alpha analysis. Conclusion. The results suggested that the expression level of BAG3 and HIF-1 alpha is efficient prognostic parameters in patients with HCC after liver transplantation.
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页数：9
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共 26 条
  • [1] The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand
    Chiappetta, Gennaro
    Ammirante, Massimo
    Basile, Anna
    Rosati, Alessandra
    Festa, Michela
    Monaco, Mario
    Vuttariello, Emilia
    Pasquinelli, Rosa
    Arra, Claudio
    Zerilli, Monica
    Todaro, Matilde
    Stassi, Giorgio
    Pezzullo, Luciano
    Gentilella, Antonio
    Tosco, Alessandra
    Pascale, Maria
    Marzullo, Liberato
    Belisario, Maria Antonietta
    Turco, Maria Caterina
    Leone, Arturo
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (03) : 1159 - 1163
  • [2] The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinoma
    Cui, Shi-Yun
    Huang, Jia-Yuan
    Chen, Yi-Tian
    Song, Hai-Zhu
    Huang, Gui-Chun
    De, Wei
    Wang, Rui
    Chen, Long-Bang
    [J]. CELL CYCLE, 2013, 12 (17) : 2849 - 2866
  • [3] A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB
    Dai, Yao
    Liu, Meilan
    Tang, Wenhua
    Li, Yongming
    Lian, Jiqin
    Lawrence, Theodore S.
    Xu, Liang
    [J]. BMC CANCER, 2009, 9 : 392
  • [4] Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress
    Dewhirst, Mark W.
    [J]. RADIATION RESEARCH, 2009, 172 (06) : 653 - 665
  • [5] Ding Lei, 2004, Zhonghua Gan Zang Bing Za Zhi, V12, P656
  • [6] BAG3 controls angiogenesis through regulation of ERK phosphorylation
    Falco, A.
    Festa, M.
    Basile, A.
    Rosati, A.
    Pascale, M.
    Florenzano, F.
    Nori, S. L.
    Nicolin, V.
    Di Benedetto, M.
    Vecchione, M. L.
    Arra, C.
    Barbieri, A.
    De Laurenzi, V.
    Turco, M. C.
    [J]. ONCOGENE, 2012, 31 (50) : 5153 - 5161
  • [7] BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy
    Festa, Michelina
    Del Valle, Luis
    Khalili, Kamel
    Franco, Renato
    Scognamiglio, Giosue
    Graziano, Vincenzo
    De Laurenzi, Vincenzo
    Turco, Maria Caterina
    Rosati, Alessandra
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (06) : 2504 - 2512
  • [8] Major causes of death among men and women in China
    He, J
    Gu, DF
    Wu, XG
    Reynolds, K
    Duan, XF
    Yao, CH
    Wang, JL
    Chen, C
    Chen, J
    Wildman, RP
    Klag, MJ
    Whelton, PK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (11) : 1124 - 1134
  • [9] Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression
    Hirota K.
    [J]. Journal of Anesthesia, 2002, 16 (2) : 150 - 159
  • [10] Huang GW, 2005, WORLD J GASTROENTERO, V11, P1705
123