Distribution and characteristics of COPD phenotypes - results from the Polish sub-cohort of the POPE study

被引：26

作者：

Kania, Aleksander ^{[1
]}

Krenke, Rafal ^{[2
]}

Kuziemski, Krzysztof ^{[3
]}

Czajkowska-Malinowska, Malgorzata ^{[4
]}

Celejewska-Wojcik, Natalia ^{[1
]}

Kuznar-Kaminska, Barbara ^{[5
]}

Farnik, Malgorzata ^{[6
]}

Bokiej, Juliusz ^{[7
]}

Miszczuk, Marta ^{[2
]}

Damps-Konstanska, Iwona ^{[3
]}

Grabicki, Marcin ^{[5
]}

Trzaska-Sobczak, Marzena ^{[6
]}

Sladek, Krzysztof ^{[1
]}

Batura-Gabryel, Halina ^{[5
]}

Barczyk, Adam ^{[6
]}

机构：

[1] Jagiellonian Univ, Med Coll, Fac Med, Dept Pulmonol,Chair Internal Med 2, Skawinska 8, PL-31066 Krakow, Poland

[2] Med Univ Warsaw, Dept Internal Med Pulm Dis & Allergy, Warsaw, Poland

[3] Med Univ Gdansk, Dept Allergol & Pneumonol, Gdansk, Poland

[4] Reg Ctr Pulmonol, Dept Lung Dis & Resp Failure, Bydgoszcz, Poland

[5] Poznan Univ Med Sci, Dept Pulmonol Allergol & Resp Oncol, Poznan, Poland

[6] Med Univ Silesia, Sch Med Katowice, Dept Pneumol, Katowice, Poland

[7] Reg Hosp Ctr Jelenia Gora, Dept Lung Dis, Jelenia Gora, Poland

来源：

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2018年 / 13卷

关键词：

chronic obstructive pulmonary disease; asthma-COPD overlap syndrome; phenotypes; OBSTRUCTIVE PULMONARY-DISEASE; OVERLAP SYNDROME ACOS; CLINICAL PHENOTYPES; GUIDELINES; ASTHMA; COMBINATION; POPULATION; SOCIETY; BIOMASS; HEALTH;

D O I：

10.2147/COPD.S154716

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: This study aimed to examine the distribution of predefined phenotypes, demographic data, clinical outcomes, and treatment of patients who were included in the Polish cohort of the Phenotypes of COPD in Central and Eastern Europe (POPE) study. Patients and methods: This was a sub-analysis of the data from the Polish cohort of the POPE study, an international, multicenter, observational cross-sectional survey of COPD patients in Central and Eastern European countries. The study included patients aged.40 years, with a confirmed diagnosis of COPD, and absence of exacerbation for at least 4 weeks before study inclusion. A total of seven Polish centers participated in the study. Results: Among the 430 Polish COPD patients enrolled in the study, 61.6% were non-exacerbators (NON-AE), 25.3% were frequent exacerbators with chronic bronchitis (AE CB), 7.9% were frequent exacerbators without chronic bronchitis (AE NON-CB), and 5.1% met the definition of asthma-COPD overlap syndrome (ACOS). There were statistically significant differences among these phenotypes in terms of symptom load, lung function, comorbidities, and treatment. Patients with the AE CB phenotype were most symptomatic with worse lung function, and more frequently reported anxiety and depression. Patients with the ACOS phenotype were significantly younger and were diagnosed with COPD earlier than those with other COPD phenotypes; those with the ACOS phenotype were also more often atopic and obese. Conclusion: There is significant heterogeneity among COPD patients in the Polish population in terms of phenotype and clinical outcome. The non-exacerbator phenotype is observed most frequently in Poland, while the frequent exacerbator with chronic bronchitis phenotype is the most symptomatic.

引用

页码：1613 / 1621

页数：9

共 35 条

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