Degradation of synthetic polymeric scaffolds for bone and cartilage tissue repairs

被引：73

作者：

Eglin, David ^{[1
]}

Mortisen, Derek ^{[1
]}

Alini, Mauro ^{[1
]}

机构：

[1] AO Res Inst, Biomat & Tissue Engn Program, CH-7270 Davos, Switzerland

来源：

SOFT MATTER | 2009年 / 5卷 / 05期

关键词：

IN-VITRO DEGRADATION; POROUS POLY(D; L-LACTIDE-CO-GLYCOLIDE); SCAFFOLDS; BIODEGRADABLE POLYURETHANE SCAFFOLDS; POLY(ETHYLENE GLYCOL); PEG HYDROGELS; HYDROLYTIC DEGRADATION; POLYESTERURETHANE FOAM; MECHANICAL-PROPERTIES; EPSILON-CAPROLACTONE; VIVO DEGRADATION;

D O I：

10.1039/b803718n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Degradation studies are reported with emphasis on polymeric scaffolds in which degradation occurs via ester bond cleavage. The temporal and structural consequences of polymer degradation on TE scaffolds in the absence and in the presence of biological components in vitro and in vivo are described and compared. Finally, the functional improvement of degradable polymeric scaffolds for TE via the formation of hybrid structures is presented.

引用

页码：938 / 947

页数：10

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