Biodistribution and accumulation of intravenously administered carbon nanotubes in mice probed by Raman spectroscopy and fluorescent labeling

被引：16

作者：

Kang, Bin ^{[1
]}

Yu, Decai ^{[2
]}

Dai, Yaodong ^{[1
]}

Chang, Shuquan ^{[1
]}

Chen, Da ^{[1
]}

Ding, Yitao ^{[2
]}

机构：

[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China

[2] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 210008, Peoples R China

来源：

CARBON | 2009年 / 47卷 / 04期

关键词：

IN-VIVO; DELIVERY; FATE;

D O I：

10.1016/j.carbon.2008.12.031

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The circulation, distribution and accumulation of intravenously administered single-walled carbon nanotubes (SWCNTs) in mice have been investigated by using the Raman spectroscopy and fluorescent labeling. The SWCNTs exhibited a rapid blood clearance with a half-life time of 3-4 h. However, rapid uptake and high levels of SWCNTs were observed in liver of mice. These SWCNTs accumulated in liver and were bard to excrete. The SWCNTs in liver led to pathological changes of liver, including injury of macrophages, cellular swelling, unspecific inflammation and blood coagulation. Similar SWCNT uptake behavior Was found in spleen and kidney, whereas, no obvious pathological changes were observed in these Organs. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1189 / 1192

页数：4

共 12 条

[1] Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence [J].

Cherukuri, Paul ;

Gannon, Christopher J. ;

Leeuw, Tonya K. ;

Schmidt, Howard K. ;

Smalley, Richard E. ;

Curley, Steven A. ;

Weisman, R. Bruce .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (50) :18882-18886

[2] Translocation and fate of multi-walled carbon nanotubes in vivo [J].

Deng, X. ;

Jia, G. ;

Wang, H. ;

Sun, H. ;

Wang, X. ;

Yang, S. ;

Wang, T. ;

Liu, Y. .

CARBON, 2007, 45 (07) :1419-1424

[3] Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons [J].

Grubek-Jaworska, H ;

Nejman, P ;

Czuminska, K ;

Przybylowski, T ;

Huczko, A ;

Lange, H ;

Bystrzejewski, M ;

Baranowski, P ;

Chazan, R .

CARBON, 2006, 44 (06) :1057-1063

[4] Biodistribution of functionalized multiwall carbon nanotubes in mice [J].

Guo, Jinxue ;

Zhang, Xiao ;

Li, Qingnuan ;

Li, Wenxin .

NUCLEAR MEDICINE AND BIOLOGY, 2007, 34 (05) :579-583

[5] Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [J].

Lewin, M ;

Carlesso, N ;

Tung, CH ;

Tang, XW ;

Cory, D ;

Scadden, DT ;

Weissleder, R .

NATURE BIOTECHNOLOGY, 2000, 18 (04) :410-414

[6] Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy [J].

Liu, Zhuang ;

Davis, Corrine ;

Cai, Weibo ;

He, Lina ;

Chen, Xiaoyuan ;

Dai, Hongjie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1410-1415

[7] Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery [J].

Liu, Zhuang ;

Sun, Xiaoming ;

Nakayama-Ratchford, Nozomi ;

Dai, Hongjie .

ACS NANO, 2007, 1 (01) :50-56

[8] Functionalized carbon nanotubes for plasmid DNA gene delivery [J].

Pantarotto, D ;

Singh, R ;

McCarthy, D ;

Erhardt, M ;

Briand, JP ;

Prato, M ;

Kostarelos, K ;

Bianco, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (39) :5242-5246

[9] A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice [J].

Schipper, Meike L. ;

Nakayama-Ratchford, Nozomi ;

Davis, Corrine R. ;

Kam, Nadine Wong Shi ;

Chu, Pauline ;

Liu, Zhuang ;

Sun, Xiaoming ;

Dai, Hongjie ;

Gambhir, Sanjiv S. .

NATURE NANOTECHNOLOGY, 2008, 3 (04) :216-221

[10] Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers [J].

Singh, R ;

Pantarotto, D ;

Lacerda, L ;

Pastorin, G ;

Klumpp, C ;

Prato, M ;

Bianco, A ;

Kostarelos, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3357-3362

← 1 2 →