Stereological studies of the schizophrenic brain

被引：24

作者：

Thune, JJ ^{[1
]}

Pakkenberg, B ^{[1
]}

机构：

[1] Kommune Hosp Copenhagen, Bartholin Inst, Neurol Res Lab, DK-1399 Copenhagen K, Denmark

来源：

BRAIN RESEARCH REVIEWS | 2000年 / 31卷 / 2-3期

关键词：

limbic system; prefrontal cortex; stereology; thalamus; total neuron number;

D O I：

10.1016/S0165-0173(99)00038-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stereological studies have contributed with important results to the understanding of brain abnormalities in schizophrenia. The data obtained from stereological studies of brains from schizophrenic patients, including studies of the thalamus, hippocampus, and cortex, are discussed and suggest a central role of the thalamic nuclei in the etiology of the: disease. The basic stereological tools are presented and possible biases in quantification studies are discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：200 / 204

页数：5

共 38 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].

ABERCROMBIE, M .

ANATOMICAL RECORD, 1946, 94 (02) :239-247

[2]

ALEXANDER GE, 1990, PROG BRAIN RES, V85, P119

[3] THALAMIC ABNORMALITIES IN SCHIZOPHRENIA VISUALIZED THROUGH MAGNETIC-RESONANCE IMAGE AVERAGING [J].

ANDREASEN, NC ;

ARNDT, S ;

SWAYZE, V ;

CIZADLO, T ;

FLAUM, M ;

OLEARY, D ;

EHRHARDT, JC ;

YUH, WTC .

SCIENCE, 1994, 266 (5183) :294-298

[4] The role of the thalamus in schizophrenia [J].

Andreasen, NC .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1997, 42 (01) :27-33

[5] The human striatum in schizophrenia .2. Increased number of striatal neurons in schizophrenics [J].

Beckmann, H ;

Lauer, M .

PSYCHIATRY RESEARCH-NEUROIMAGING, 1997, 68 (2-3) :99-109

[6] Up-regulation of GABA(A) receptor binding on neurons of the prefrontal cortex in schizophrenic subjects [J].

Benes, FM ;

Vincent, SL ;

Marie, A ;

Khan, Y .

NEUROSCIENCE, 1996, 75 (04) :1021-1031

[7]

BENES FM, 1991, ARCH GEN PSYCHIAT, V48, P996

[8]

BENES FM, 1986, ARCH GEN PSYCHIAT, V43, P31

[9] The temporolimbic system theory of positive schizophrenic symptoms [J].

Bogerts, B .

SCHIZOPHRENIA BULLETIN, 1997, 23 (03) :423-435

[10]

Buchsbaum MS, 1996, AM J PSYCHIAT, V153, P191

← 1 2 3 4 →