Metachronous bilateral mammary metaplastic and infiltrating duct carcinomas: A molecular study for clonality

被引：18
作者：
Kung, FYL
Tse, GMK
Lo, KW
Law, BKB
Chang, AR
Chen, MH
机构：
[1] Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
[2] Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
[3] PH Chan Med Labs Ltd, Hong Kong, Hong Kong, Peoples R China
来源：
HUMAN PATHOLOGY | 2002年 / 33卷 / 06期
关键词：
metaplastic carcinoma; carcinosarcoma; loss of heterozygosity;
D O I：
10.1053/hupa.2002.124906
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Mammary metaplastic carcinoma is uncommon. In this study, both carcinoma and sarcoma components of a metaplastic carcinoma and a subsequent metachronous contralateral infiltrating ductal carcinoma were analyzed by microsatellite analysis for the loss of heterozygosity (LOH) patterns at multiple sites on chromosome arms 3p, 6q, 8, 9p, 11, 13q, 14q, 16q, and 17p. The LOH patterns between the carcinoma and sarcoma components in the first tumor were similar, indicating clonality. The LOH patterns between the first and second tumors were different at all chromosome arms, indicating different clonality and a second primary. We demonstrated a second primary carcinoma in a patient with previous metaplastic carcinoma rather than a metastasis with carcinoma component only. Copyright 2002, Elsevier Science (USA). All rights reserved.
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收藏
页码：677 / 679
页数：3
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