Absolute immature platelet count helps differentiate thrombotic thrombocytopenic purpura from hypertension-induced thrombotic microangiopathy

被引：15

作者：

Zheng, Yan ^{[1
,2
]}

Hong, Hong ^{[1
,2
]}

Reeves, Hollie M. ^{[1
,2
]}

Maitta, Robert W. ^{[1
,2
]}

机构：

[1] Univ Hosp, Case Med Ctr, Dept Pathol, Cleveland, OH USA

[2] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2014年 / 51卷 / 01期

关键词：

Absolute immature platelet count; %-IPF; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura; Hypertension; Therapeutic plasma exchange; MALIGNANT HYPERTENSION; ADAMTS13; FRACTION;

D O I：

10.1016/j.transci.2014.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ADAmTs13 activity measurement is used in the diagnostic algorithm of thrombotic thrombocytopenic purpura (UP), but results may not be available before initiation of therapeutic plasma exchange (TPE). The immature platelet fraction (%-IPF) and the calculated absolute immature platelet count (A-IPC) represent a test of real-time thrombopoiesis, and can be performed in most laboratories using automated analyzers. Here we report on using A-IPC kinetics to exclude idiopathic TTP in a patient with severe hypertension, thrombocytopenia, and acute renal failure, which was confirmed by a normal ADAMTS13. The complete resolution of thrombocytopenia occurred once blood pressure was controlled favoring a diagnosis of hypertension-induced thrombotic microangiopathy. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：54 / 57

页数：4

共 27 条

[1] Absolute immature platelet count dynamics of thrombotic thrombocytopenic purpura patients with high ADAMTS13 inhibitor
Gokozan, Hamza N.
Reeves, Hollie M.
Maitta, Robert W.
THROMBOSIS RESEARCH, 2019, 179 : 128 - 131
[2] Differentiating malignant hypertensioninduced thrombotic microangiopathy from thrombotic thrombocytopenic purpura
Khanal, Nabin
Dahal, Sumit
Upadhyay, Smrity
Bhatt, Vijaya Raj
Bierman, Philip J.
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2015, 6 (03) : 97 - 102
[3] Absolute immature platelet count dynamics in diagnosing and monitoring the clinical course of thrombotic thrombocytopenic purpura
Hong, Hong
Xiao, Wenbin
Stempak, Lisa M.
Sandhaus, Linda M.
Maitta, Robert W.
TRANSFUSION, 2015, 55 (04) : 756 - 765
[4] Comparison of absolute immature platelet count to the PLASMIC score at presentation in predicting ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura
Reeves, Hollie M.
Maitta, Robert W.
THROMBOSIS RESEARCH, 2022, 215 : 30 - 36
[5] Absolute Immature Platelet Counts Suggest Platelet Production Suppression during Complicated Relapsing Thrombotic Thrombocytopenic Purpura
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Reeves, Hollie M.
Maitta, Robert W.
ACTA HAEMATOLOGICA, 2021, 144 (04) : 465 - 469
[6] Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP): Can we differentiate one from the other?
Shibagaki, Y
Fujita, T
HYPERTENSION RESEARCH, 2005, 28 (01) : 89 - 95
[7] Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?
Yugo Shibagaki
Toshiro Fujita
Hypertension Research, 2005, 28 : 89 - 95
[8] Dynamic changes in absolute immature platelet count suggest the presence of a coexisting immune process in the setting of thrombotic thrombocytopenic purpura
Stefaniuk, Catherine M.
Reeves, Hollie M.
Maitta, Robert W.
TRANSFUSION, 2017, 57 (04) : 913 - 918
[9] COVID-19-induced thrombotic microangiopathy: A great mimicker of thrombotic thrombocytopenic purpura (TTP)
Warnecke, Brian
Kapoor, Vidit
Wehbe, Alexandra
Datta, Paromita
CLINICAL CASE REPORTS, 2023, 11 (01):
[10] Immature platelet count responses of pediatric patients with immune-mediated thrombotic thrombocytopenic purpura
Reeves, Hollie M.
Zhu, Meng-Lei
Maitta, Robert W.
THROMBOSIS RESEARCH, 2024, 241

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